Topical TRPM8 Agonist for Relieving Neuropathic Ocular Pain in Patients with Dry Eye: A Pilot Study
Background: Activation of TRPM8, a cold-sensing receptor located on the cornea and eyelid, has the potential to relieve the neuropathic ocular pain (NOP) in dry eye (DE) by inhibiting other aberrant nociceptive inputs. We aimed to investigate the effect of a topical TRPM8 agonist, cryosim-3 (C3), on...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-01-01
|
Series: | Journal of Clinical Medicine |
Subjects: | |
Online Access: | https://www.mdpi.com/2077-0383/10/2/250 |
id |
doaj-2bf3a36d93924d94847223ca5e962fe8 |
---|---|
record_format |
Article |
spelling |
doaj-2bf3a36d93924d94847223ca5e962fe82021-01-13T00:01:20ZengMDPI AGJournal of Clinical Medicine2077-03832021-01-011025025010.3390/jcm10020250Topical TRPM8 Agonist for Relieving Neuropathic Ocular Pain in Patients with Dry Eye: A Pilot StudyHyeon Jeong Yoon0Jonghwa Kim1Jee Myung Yang2Edward T. Wei3Seong Jin Kim4Kyung Chul Yoon5Department of Ophthalmology, Chonnam National University Medical School and Hospital, 42 Jebong-ro, Dong-gu, Gwangju 61469, KoreaDepartment of Ophthalmology, Chonnam National University Medical School and Hospital, 42 Jebong-ro, Dong-gu, Gwangju 61469, KoreaDepartment of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-Ro 43 Gil, Songpa-gu, Seoul 05505, KoreaSchool of Public Health, University of California, Berkeley, CA 94720, USADepartment of Dermatology, Chonnam National University Medical School and Hospital, 42 Jebong-ro, Dong-gu, Gwangju 61469, KoreaDepartment of Ophthalmology, Chonnam National University Medical School and Hospital, 42 Jebong-ro, Dong-gu, Gwangju 61469, KoreaBackground: Activation of TRPM8, a cold-sensing receptor located on the cornea and eyelid, has the potential to relieve the neuropathic ocular pain (NOP) in dry eye (DE) by inhibiting other aberrant nociceptive inputs. We aimed to investigate the effect of a topical TRPM8 agonist, cryosim-3 (C3), on relieving DE-associated NOP. Methods: We conducted a prospective pilot study of 15 patients with DE-associated NOP. These patients applied topical C3 to their eyelid, 4 times/day for 1 month. The patients underwent clinical examinations. They also completed the Ocular Pain Assessment Survey (OPAS), which is a validated questionnaire for NOP, at baseline, 1 week, and 1 month after treatment. Result: At 1 week, the OPAS scores of eye pain intensity, quality of life (driving/watching TV, general activity, sleep, and enjoying life/relations with other people), and associated factors (burning sensation, light sensitivity, and tearing) improved. The total OPAS scores of eye pain intensity, quality of life, and associated factors remained improved at 1 month. The Schirmer test scores also improved at 1 month. Conclusion: TRPM8 agonist (C3) could be a novel agent for treating patients with DE-associated NOP who are unresponsive to conventional treatments.https://www.mdpi.com/2077-0383/10/2/250TRPM8 agonistcryosim-3dry eyeneuropathic pain |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hyeon Jeong Yoon Jonghwa Kim Jee Myung Yang Edward T. Wei Seong Jin Kim Kyung Chul Yoon |
spellingShingle |
Hyeon Jeong Yoon Jonghwa Kim Jee Myung Yang Edward T. Wei Seong Jin Kim Kyung Chul Yoon Topical TRPM8 Agonist for Relieving Neuropathic Ocular Pain in Patients with Dry Eye: A Pilot Study Journal of Clinical Medicine TRPM8 agonist cryosim-3 dry eye neuropathic pain |
author_facet |
Hyeon Jeong Yoon Jonghwa Kim Jee Myung Yang Edward T. Wei Seong Jin Kim Kyung Chul Yoon |
author_sort |
Hyeon Jeong Yoon |
title |
Topical TRPM8 Agonist for Relieving Neuropathic Ocular Pain in Patients with Dry Eye: A Pilot Study |
title_short |
Topical TRPM8 Agonist for Relieving Neuropathic Ocular Pain in Patients with Dry Eye: A Pilot Study |
title_full |
Topical TRPM8 Agonist for Relieving Neuropathic Ocular Pain in Patients with Dry Eye: A Pilot Study |
title_fullStr |
Topical TRPM8 Agonist for Relieving Neuropathic Ocular Pain in Patients with Dry Eye: A Pilot Study |
title_full_unstemmed |
Topical TRPM8 Agonist for Relieving Neuropathic Ocular Pain in Patients with Dry Eye: A Pilot Study |
title_sort |
topical trpm8 agonist for relieving neuropathic ocular pain in patients with dry eye: a pilot study |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2021-01-01 |
description |
Background: Activation of TRPM8, a cold-sensing receptor located on the cornea and eyelid, has the potential to relieve the neuropathic ocular pain (NOP) in dry eye (DE) by inhibiting other aberrant nociceptive inputs. We aimed to investigate the effect of a topical TRPM8 agonist, cryosim-3 (C3), on relieving DE-associated NOP. Methods: We conducted a prospective pilot study of 15 patients with DE-associated NOP. These patients applied topical C3 to their eyelid, 4 times/day for 1 month. The patients underwent clinical examinations. They also completed the Ocular Pain Assessment Survey (OPAS), which is a validated questionnaire for NOP, at baseline, 1 week, and 1 month after treatment. Result: At 1 week, the OPAS scores of eye pain intensity, quality of life (driving/watching TV, general activity, sleep, and enjoying life/relations with other people), and associated factors (burning sensation, light sensitivity, and tearing) improved. The total OPAS scores of eye pain intensity, quality of life, and associated factors remained improved at 1 month. The Schirmer test scores also improved at 1 month. Conclusion: TRPM8 agonist (C3) could be a novel agent for treating patients with DE-associated NOP who are unresponsive to conventional treatments. |
topic |
TRPM8 agonist cryosim-3 dry eye neuropathic pain |
url |
https://www.mdpi.com/2077-0383/10/2/250 |
work_keys_str_mv |
AT hyeonjeongyoon topicaltrpm8agonistforrelievingneuropathicocularpaininpatientswithdryeyeapilotstudy AT jonghwakim topicaltrpm8agonistforrelievingneuropathicocularpaininpatientswithdryeyeapilotstudy AT jeemyungyang topicaltrpm8agonistforrelievingneuropathicocularpaininpatientswithdryeyeapilotstudy AT edwardtwei topicaltrpm8agonistforrelievingneuropathicocularpaininpatientswithdryeyeapilotstudy AT seongjinkim topicaltrpm8agonistforrelievingneuropathicocularpaininpatientswithdryeyeapilotstudy AT kyungchulyoon topicaltrpm8agonistforrelievingneuropathicocularpaininpatientswithdryeyeapilotstudy |
_version_ |
1724339723454906368 |