Real-time self-regulation of emotion networks in patients with depression.
Many patients show no or incomplete responses to current pharmacological or psychological therapies for depression. Here we explored the feasibility of a new brain self-regulation technique that integrates psychological and neurobiological approaches through neurofeedback with functional magnetic re...
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2012-01-01
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doaj-2bf5e49403054a78ba01d9363470719c2020-11-24T21:49:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0176e3811510.1371/journal.pone.0038115Real-time self-regulation of emotion networks in patients with depression.David E J LindenIsabelle HabesStephen J JohnstonStefanie LindenRanjit TatineniLeena SubramanianBettina SorgerDavid HealyRainer GoebelMany patients show no or incomplete responses to current pharmacological or psychological therapies for depression. Here we explored the feasibility of a new brain self-regulation technique that integrates psychological and neurobiological approaches through neurofeedback with functional magnetic resonance imaging (fMRI). In a proof-of-concept study, eight patients with depression learned to upregulate brain areas involved in the generation of positive emotions (such as the ventrolateral prefrontal cortex (VLPFC) and insula) during four neurofeedback sessions. Their clinical symptoms, as assessed with the 17-item Hamilton Rating Scale for Depression (HDRS), improved significantly. A control group that underwent a training procedure with the same cognitive strategies but without neurofeedback did not improve clinically. Randomised blinded clinical trials are now needed to exclude possible placebo effects and to determine whether fMRI-based neurofeedback might become a useful adjunct to current therapies for depression.http://europepmc.org/articles/PMC3366978?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
David E J Linden Isabelle Habes Stephen J Johnston Stefanie Linden Ranjit Tatineni Leena Subramanian Bettina Sorger David Healy Rainer Goebel |
spellingShingle |
David E J Linden Isabelle Habes Stephen J Johnston Stefanie Linden Ranjit Tatineni Leena Subramanian Bettina Sorger David Healy Rainer Goebel Real-time self-regulation of emotion networks in patients with depression. PLoS ONE |
author_facet |
David E J Linden Isabelle Habes Stephen J Johnston Stefanie Linden Ranjit Tatineni Leena Subramanian Bettina Sorger David Healy Rainer Goebel |
author_sort |
David E J Linden |
title |
Real-time self-regulation of emotion networks in patients with depression. |
title_short |
Real-time self-regulation of emotion networks in patients with depression. |
title_full |
Real-time self-regulation of emotion networks in patients with depression. |
title_fullStr |
Real-time self-regulation of emotion networks in patients with depression. |
title_full_unstemmed |
Real-time self-regulation of emotion networks in patients with depression. |
title_sort |
real-time self-regulation of emotion networks in patients with depression. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2012-01-01 |
description |
Many patients show no or incomplete responses to current pharmacological or psychological therapies for depression. Here we explored the feasibility of a new brain self-regulation technique that integrates psychological and neurobiological approaches through neurofeedback with functional magnetic resonance imaging (fMRI). In a proof-of-concept study, eight patients with depression learned to upregulate brain areas involved in the generation of positive emotions (such as the ventrolateral prefrontal cortex (VLPFC) and insula) during four neurofeedback sessions. Their clinical symptoms, as assessed with the 17-item Hamilton Rating Scale for Depression (HDRS), improved significantly. A control group that underwent a training procedure with the same cognitive strategies but without neurofeedback did not improve clinically. Randomised blinded clinical trials are now needed to exclude possible placebo effects and to determine whether fMRI-based neurofeedback might become a useful adjunct to current therapies for depression. |
url |
http://europepmc.org/articles/PMC3366978?pdf=render |
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