Anti-Epileptic Drug Toxicity in Children
Anti-epileptic drugs (AEDs) have had a major impact on children, improving their quality of life and significantly reducing both morbidity and mortality. They are, however, associated with significant toxicity. Behavioural problems and somnolence are the most frequent adverse drug reactions for many...
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Online Access: | http://www.mdpi.com/2227-9067/5/5/57 |
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doaj-2bfefd86bfaa4edca4b8d7dcc6da7dda2021-04-02T11:06:48ZengMDPI AGChildren2227-90672018-05-01555710.3390/children5050057children5050057Anti-Epileptic Drug Toxicity in ChildrenImti Choonara0Academic Division of Child Health, The Medical School, University of Nottingham, Derbyshire Children’s Hospital, Derby DE22 3DT, UKAnti-epileptic drugs (AEDs) have had a major impact on children, improving their quality of life and significantly reducing both morbidity and mortality. They are, however, associated with significant toxicity. Behavioural problems and somnolence are the most frequent adverse drug reactions for many AEDs. Unfortunately, the comparative risk of drug toxicity for different AEDs has been inadequately studied. Drug toxicity is poorly reported in randomised controlled trials. Prospective cohort studies are the best way to study drug toxicity. There have been a few prospective cohort studies of children with epilepsy, but the numbers of children have been small. Systemic reviews of the toxicity of individual AEDs have been helpful in identifying the risk of drug toxicity. Parents of children with epilepsy and the children and young people who are due to receive AED treatment have the right to know the likelihood of them experiencing drug toxicity. Unfortunately, the evidence base on which health professionals can provide such information is limited.http://www.mdpi.com/2227-9067/5/5/57drug toxicityantiepileptic drugbehavioural problemsvalproatelamotriginelevetiracetam |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Imti Choonara |
spellingShingle |
Imti Choonara Anti-Epileptic Drug Toxicity in Children Children drug toxicity antiepileptic drug behavioural problems valproate lamotrigine levetiracetam |
author_facet |
Imti Choonara |
author_sort |
Imti Choonara |
title |
Anti-Epileptic Drug Toxicity in Children |
title_short |
Anti-Epileptic Drug Toxicity in Children |
title_full |
Anti-Epileptic Drug Toxicity in Children |
title_fullStr |
Anti-Epileptic Drug Toxicity in Children |
title_full_unstemmed |
Anti-Epileptic Drug Toxicity in Children |
title_sort |
anti-epileptic drug toxicity in children |
publisher |
MDPI AG |
series |
Children |
issn |
2227-9067 |
publishDate |
2018-05-01 |
description |
Anti-epileptic drugs (AEDs) have had a major impact on children, improving their quality of life and significantly reducing both morbidity and mortality. They are, however, associated with significant toxicity. Behavioural problems and somnolence are the most frequent adverse drug reactions for many AEDs. Unfortunately, the comparative risk of drug toxicity for different AEDs has been inadequately studied. Drug toxicity is poorly reported in randomised controlled trials. Prospective cohort studies are the best way to study drug toxicity. There have been a few prospective cohort studies of children with epilepsy, but the numbers of children have been small. Systemic reviews of the toxicity of individual AEDs have been helpful in identifying the risk of drug toxicity. Parents of children with epilepsy and the children and young people who are due to receive AED treatment have the right to know the likelihood of them experiencing drug toxicity. Unfortunately, the evidence base on which health professionals can provide such information is limited. |
topic |
drug toxicity antiepileptic drug behavioural problems valproate lamotrigine levetiracetam |
url |
http://www.mdpi.com/2227-9067/5/5/57 |
work_keys_str_mv |
AT imtichoonara antiepilepticdrugtoxicityinchildren |
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