Ras enhances TGF-β signaling by decreasing cellular protein levels of its type II receptor negative regulator SPSB1

Ras enhances TGF-β signaling by decreasing cellular protein levels of its type II receptor negative regulator SPSB1

Abstract Background Transformation by oncogene Ras overcomes TGF-β mediated growth inhibition in epithelial cells. However, it cooperates with each other to mediate epithelial to mesenchymal transition (EMT). The mechanism of how these two pathways interact with each other is controversial. Methods...

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Bibliographic Details
Main Authors: Sheng Liu, Josephine Iaria, Richard J. Simpson, Hong-Jian Zhu
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Cell Communication and Signaling
Subjects:
Ras
SPSB1
TGF-β signaling
Online Access:http://link.springer.com/article/10.1186/s12964-018-0223-4

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