Cathepsin-D, a key protease in breast cancer, is up-regulated in obese mouse and human adipose tissue, and controls adipogenesis.
The aspartic protease cathepsin-D (cath-D) is overexpressed by human epithelial breast cancer cells and is closely correlated with poor prognosis in breast cancer. The adipocyte is one of the most prominent cell types in the tumor-microenvironment of breast cancer, and clinical studies have shown th...
Main Authors: | Olivier Masson, Christine Prébois, Danielle Derocq, Aline Meulle, Cédric Dray, Danielle Daviaud, Didier Quilliot, Philippe Valet, Catherine Muller, Emmanuelle Liaudet-Coopman |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2011-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3032791?pdf=render |
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