Role of Nicotinamide in DNA Damage, Mutagenesis, and DNA Repair
Nicotinamide is a water-soluble amide form of niacin (nicotinic acid or vitamin B3). Both niacin and nicotinamide are widely available in plant and animal foods, and niacin can also be endogenously synthesized in the liver from dietary tryptophan. Nicotinamide is also commercially available in vita...
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Online Access: | http://dx.doi.org/10.4061/2010/157591 |
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doaj-2c020d368ca049d19c7cf0019a784f882020-11-24T23:13:42ZengHindawi LimitedJournal of Nucleic Acids2090-021X2010-01-01201010.4061/2010/157591157591Role of Nicotinamide in DNA Damage, Mutagenesis, and DNA RepairDevita Surjana0Gary M. Halliday1Diona L. Damian2Discipline of Dermatology, Sydney Cancer Centre, Bosch Institute, University of Sydney at Royal Prince Alfred Hospital, Camperdown, Sydney, NSW 2006, AustraliaDiscipline of Dermatology, Sydney Cancer Centre, Bosch Institute, University of Sydney at Royal Prince Alfred Hospital, Camperdown, Sydney, NSW 2006, AustraliaDiscipline of Dermatology, Sydney Cancer Centre, Bosch Institute, University of Sydney at Royal Prince Alfred Hospital, Camperdown, Sydney, NSW 2006, AustraliaNicotinamide is a water-soluble amide form of niacin (nicotinic acid or vitamin B3). Both niacin and nicotinamide are widely available in plant and animal foods, and niacin can also be endogenously synthesized in the liver from dietary tryptophan. Nicotinamide is also commercially available in vitamin supplements and in a range of cosmetic, hair, and skin preparations. Nicotinamide is the primary precursor of nicotinamide adenine dinucleotide (NAD+), an essential coenzyme in ATP production and the sole substrate of the nuclear enzyme poly-ADP-ribose polymerase-1 (PARP-1). Numerous in vitro and in vivo studies have clearly shown that PARP-1 and NAD+ status influence cellular responses to genotoxicity which can lead to mutagenesis and cancer formation. This paper will examine the role of nicotinamide in the protection from carcinogenesis, DNA repair, and maintenance of genomic stability.http://dx.doi.org/10.4061/2010/157591 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Devita Surjana Gary M. Halliday Diona L. Damian |
spellingShingle |
Devita Surjana Gary M. Halliday Diona L. Damian Role of Nicotinamide in DNA Damage, Mutagenesis, and DNA Repair Journal of Nucleic Acids |
author_facet |
Devita Surjana Gary M. Halliday Diona L. Damian |
author_sort |
Devita Surjana |
title |
Role of Nicotinamide in DNA Damage, Mutagenesis, and DNA Repair |
title_short |
Role of Nicotinamide in DNA Damage, Mutagenesis, and DNA Repair |
title_full |
Role of Nicotinamide in DNA Damage, Mutagenesis, and DNA Repair |
title_fullStr |
Role of Nicotinamide in DNA Damage, Mutagenesis, and DNA Repair |
title_full_unstemmed |
Role of Nicotinamide in DNA Damage, Mutagenesis, and DNA Repair |
title_sort |
role of nicotinamide in dna damage, mutagenesis, and dna repair |
publisher |
Hindawi Limited |
series |
Journal of Nucleic Acids |
issn |
2090-021X |
publishDate |
2010-01-01 |
description |
Nicotinamide is a water-soluble amide form of niacin (nicotinic acid or vitamin B3). Both niacin and nicotinamide are widely available in plant and animal foods, and niacin can also be endogenously synthesized in the liver from dietary tryptophan. Nicotinamide is also commercially available in vitamin supplements and in a range of cosmetic, hair, and skin preparations. Nicotinamide is the primary precursor of nicotinamide adenine dinucleotide (NAD+), an essential coenzyme in ATP production and the sole substrate of the nuclear enzyme poly-ADP-ribose polymerase-1 (PARP-1). Numerous in vitro and in vivo studies have clearly shown that PARP-1 and NAD+ status influence cellular responses to genotoxicity which can lead to mutagenesis and cancer formation. This paper will examine the role of nicotinamide in the protection from carcinogenesis, DNA repair, and maintenance of genomic stability. |
url |
http://dx.doi.org/10.4061/2010/157591 |
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