Determination of cholinesterase inhibition potential of rose extract
Rosa Damascena Mill., also known as oil rose or rose of Isparta, is one of the most important roses among the fragrant roses in the world. The essential oil obtained from Isparta rose is used especially in cosmetics, perfumery, pharmaceutical and food industries. Isparta rose is traditionally used i...
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Ondokuz Mayıs University
2018-10-01
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Online Access: | http://dergipark.gov.tr/omuanajas/issue/39717/465971 |
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doaj-2c1a2d6eda9d4f1fb051b2044743b08a2020-11-24T21:00:31ZengOndokuz Mayıs UniversityAnadolu Tarım Bilimleri Dergisi1308-87501308-87692018-10-0133323724010.7161/omuanajas.465971Determination of cholinesterase inhibition potential of rose extractEsra ŞentürkMurat ŞentürkRosa Damascena Mill., also known as oil rose or rose of Isparta, is one of the most important roses among the fragrant roses in the world. The essential oil obtained from Isparta rose is used especially in cosmetics, perfumery, pharmaceutical and food industries. Isparta rose is traditionally used in the treatment of chest and abdominal pain, strengthening of the heart, constipation, digestive problems and is used in the treatment of neural diseases. Although pathogenesis of Alzheimer’s disease (AD) has not been clarified as yet, one of the most accepted theories has been ‘‘cholinergic hypothesis”. A deficiency in levels of the neuromediators called acetylcholine (ACh) and butyrylcholine (BCh) has been observed in the brains of AD patients. Inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), the main enzymes which hydrolyze ACh and BCh, respectively, has happen a major treatment option towards AD. So, we initiated a study to screen their AChE and BChE inhibitory activities, which are the key enzymes taking place in pathogenesis of AD. For this purpose, we investigated the effects of rose water on these enzymes. IC50 values were determined as 0.6227 µg ml-1 for AChE and 0.1956 μg/ml for BChE.http://dergipark.gov.tr/omuanajas/issue/39717/465971Rosa damascenaAlzheimerAcetylcholinesteraseButyrylcholinesteraseInhibition |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Esra Şentürk Murat Şentürk |
spellingShingle |
Esra Şentürk Murat Şentürk Determination of cholinesterase inhibition potential of rose extract Anadolu Tarım Bilimleri Dergisi Rosa damascena Alzheimer Acetylcholinesterase Butyrylcholinesterase Inhibition |
author_facet |
Esra Şentürk Murat Şentürk |
author_sort |
Esra Şentürk |
title |
Determination of cholinesterase inhibition potential of rose extract |
title_short |
Determination of cholinesterase inhibition potential of rose extract |
title_full |
Determination of cholinesterase inhibition potential of rose extract |
title_fullStr |
Determination of cholinesterase inhibition potential of rose extract |
title_full_unstemmed |
Determination of cholinesterase inhibition potential of rose extract |
title_sort |
determination of cholinesterase inhibition potential of rose extract |
publisher |
Ondokuz Mayıs University |
series |
Anadolu Tarım Bilimleri Dergisi |
issn |
1308-8750 1308-8769 |
publishDate |
2018-10-01 |
description |
Rosa Damascena Mill., also known as oil rose or rose of Isparta, is one of the most important roses among the fragrant roses in the world. The essential oil obtained from Isparta rose is used especially in cosmetics, perfumery, pharmaceutical and food industries. Isparta rose is traditionally used in the treatment of chest and abdominal pain, strengthening of the heart, constipation, digestive problems and is used in the treatment of neural diseases. Although pathogenesis of Alzheimer’s disease (AD) has not been clarified as yet, one of the most accepted theories has been ‘‘cholinergic hypothesis”. A deficiency in levels of the neuromediators called acetylcholine (ACh) and butyrylcholine (BCh) has been observed in the brains of AD patients. Inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), the main enzymes which hydrolyze ACh and BCh, respectively, has happen a major treatment option towards AD. So, we initiated a study to screen their AChE and BChE inhibitory activities, which are the key enzymes taking place in pathogenesis of AD. For this purpose, we investigated the effects of rose water on these enzymes. IC50 values were determined as 0.6227 µg ml-1 for AChE and 0.1956 μg/ml for BChE. |
topic |
Rosa damascena Alzheimer Acetylcholinesterase Butyrylcholinesterase Inhibition |
url |
http://dergipark.gov.tr/omuanajas/issue/39717/465971 |
work_keys_str_mv |
AT esrasenturk determinationofcholinesteraseinhibitionpotentialofroseextract AT muratsenturk determinationofcholinesteraseinhibitionpotentialofroseextract |
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1716779511779950592 |