Effects of Aging on Hair Color, Melanosome Morphology, and Melanin Composition in Japanese Females
In a previous study, we showed that the size of melanosomes isolated from Japanese female hairs enlarges with age, and this affects the hair color. In this study, we analyzed the age-dependent changes in hair melanin in order to further explore the factors related to hair color changing by aging. A...
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doaj-2c1b2656fe0749228c39289c44a9bd232020-11-25T01:57:18ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-07-012015373910.3390/ijms20153739ijms20153739Effects of Aging on Hair Color, Melanosome Morphology, and Melanin Composition in Japanese FemalesTakashi Itou0Shosuke Ito1Kazumasa Wakamatsu2Kao Corporation, R&D - Hair Care Products Research, Tokyo 131-8501, JapanDepartment of Chemistry, Fujita Health University School of Medical Sciences, Toyoake, Aichi 470-1192, JapanDepartment of Chemistry, Fujita Health University School of Medical Sciences, Toyoake, Aichi 470-1192, JapanIn a previous study, we showed that the size of melanosomes isolated from Japanese female hairs enlarges with age, and this affects the hair color. In this study, we analyzed the age-dependent changes in hair melanin in order to further explore the factors related to hair color changing by aging. A significant positive correlation with age was found in the total melanin amount (TM) and the mol% of 5,6-dihydroxyindole (DHI) units, while no correlation was found in pheomelanin mol%. TM showed significant correlations with hair color parameters and the melanosome volume, suggesting that hair color darkening by aging is caused by the increase in TM due to the enlargement of the size of melanosome. From the measurement of absorbance spectra on synthetic eumelanins with different ratios of DHI and 5,6-dihydroxyindole-2-carboxylic acid (DHICA), we found that the increase in DHI mol% also contributes to the darkening of hair color by aging. In addition, the level of pyrrole-2,3-dicarboxylic acid (PDCA), a marker of DHI melanin, showed a significant negative correlation with the aspect ratio of melanosome, suggesting a contribution of DHI melanin to the change in melanosome morphology by aging.https://www.mdpi.com/1422-0067/20/15/3739hairagingmelanosomemorphologymelanin5,6-dihydroxyindole5,6-dihydroxyindole-2-carboxylic acid |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Takashi Itou Shosuke Ito Kazumasa Wakamatsu |
spellingShingle |
Takashi Itou Shosuke Ito Kazumasa Wakamatsu Effects of Aging on Hair Color, Melanosome Morphology, and Melanin Composition in Japanese Females International Journal of Molecular Sciences hair aging melanosome morphology melanin 5,6-dihydroxyindole 5,6-dihydroxyindole-2-carboxylic acid |
author_facet |
Takashi Itou Shosuke Ito Kazumasa Wakamatsu |
author_sort |
Takashi Itou |
title |
Effects of Aging on Hair Color, Melanosome Morphology, and Melanin Composition in Japanese Females |
title_short |
Effects of Aging on Hair Color, Melanosome Morphology, and Melanin Composition in Japanese Females |
title_full |
Effects of Aging on Hair Color, Melanosome Morphology, and Melanin Composition in Japanese Females |
title_fullStr |
Effects of Aging on Hair Color, Melanosome Morphology, and Melanin Composition in Japanese Females |
title_full_unstemmed |
Effects of Aging on Hair Color, Melanosome Morphology, and Melanin Composition in Japanese Females |
title_sort |
effects of aging on hair color, melanosome morphology, and melanin composition in japanese females |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-07-01 |
description |
In a previous study, we showed that the size of melanosomes isolated from Japanese female hairs enlarges with age, and this affects the hair color. In this study, we analyzed the age-dependent changes in hair melanin in order to further explore the factors related to hair color changing by aging. A significant positive correlation with age was found in the total melanin amount (TM) and the mol% of 5,6-dihydroxyindole (DHI) units, while no correlation was found in pheomelanin mol%. TM showed significant correlations with hair color parameters and the melanosome volume, suggesting that hair color darkening by aging is caused by the increase in TM due to the enlargement of the size of melanosome. From the measurement of absorbance spectra on synthetic eumelanins with different ratios of DHI and 5,6-dihydroxyindole-2-carboxylic acid (DHICA), we found that the increase in DHI mol% also contributes to the darkening of hair color by aging. In addition, the level of pyrrole-2,3-dicarboxylic acid (PDCA), a marker of DHI melanin, showed a significant negative correlation with the aspect ratio of melanosome, suggesting a contribution of DHI melanin to the change in melanosome morphology by aging. |
topic |
hair aging melanosome morphology melanin 5,6-dihydroxyindole 5,6-dihydroxyindole-2-carboxylic acid |
url |
https://www.mdpi.com/1422-0067/20/15/3739 |
work_keys_str_mv |
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