Association between Cervical Spondylosis and Migraine: A Nationwide Retrospective Cohort Study
Background: Few studies have investigated the longitudinal association between cervical spondylosis (CS) and migraine by using a nationwide population-based database. Methods: We conducted a retrospective cohort study from 2000 to 2011 identifying 27,930 cases of cervical spondylosis and 111,720 con...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2018-03-01
|
Series: | International Journal of Environmental Research and Public Health |
Subjects: | |
Online Access: | http://www.mdpi.com/1660-4601/15/4/587 |
id |
doaj-2c1d647590004c43a22e8048c56b8fcb |
---|---|
record_format |
Article |
spelling |
doaj-2c1d647590004c43a22e8048c56b8fcb2020-11-25T00:12:21ZengMDPI AGInternational Journal of Environmental Research and Public Health1660-46012018-03-0115458710.3390/ijerph15040587ijerph15040587Association between Cervical Spondylosis and Migraine: A Nationwide Retrospective Cohort StudyWang-Sheng Lin0Tung-Fu Huang1Tien-Yow Chuang2Cheng-Li Lin3Chia-Hung Kao4Department of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital, Taipei 11217, TaiwanDepartment of Surgery, Faculty of Medicine, National Yang-Ming University, Taipei 11221, TaiwanDepartment of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital, Taipei 11217, TaiwanManagement Office for Health Data, China Medical University Hospital, Taichung 404, TaiwanGraduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, No. 2, Yuh-Der Road, Taichung 404, TaiwanBackground: Few studies have investigated the longitudinal association between cervical spondylosis (CS) and migraine by using a nationwide population-based database. Methods: We conducted a retrospective cohort study from 2000 to 2011 identifying 27,930 cases of cervical spondylosis and 111,720 control subjects (those without cervical spondylosis) from a single database. The subjects were frequency-matched on the basis of sex, age, and diagnosis date. The non- cervical spondylosis cohort was four times the size of the cervical spondylosis cohort. To quantify the effects of cervical spondylosis on the risk of migraine, univariate and multivariate Cox proportional hazard regression analyses were used to calculate the hazard ratio (HR), and 95% confidence interval (CI). Results: After a 10-year follow-up controlling for potential confounding factors, overall migraine incidence was higher in the cervical spondylosis cohort than in the non-cervical spondylosis cohort (5.16 and 2.09 per 1000 people per year, respectively; crude hazard ratio = 2.48, 95% confidence interval = 2.28–2.69), with an adjusted hazard ratio of 2.03 (95% confidence interval = 1.86–2.22) after accounting for sex, age, comorbidities, and medication. Individuals with myelopathy in the cervical spondylosis cohort had a 2.19 times (95% confidence interval = 1.80–2.66) higher incidence of migraine when compared than did those in the non- cervical spondylosis cohort. Conclusions: Individuals with cervical spondylosis exhibited a higher risk of migraine than those without cervical spondylosis. The migraine incidence rate was even higher among individuals with cervical spondylotic myelopathy.http://www.mdpi.com/1660-4601/15/4/587cervical spondylosismigraineretrospective cohort studypopulation-based |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wang-Sheng Lin Tung-Fu Huang Tien-Yow Chuang Cheng-Li Lin Chia-Hung Kao |
spellingShingle |
Wang-Sheng Lin Tung-Fu Huang Tien-Yow Chuang Cheng-Li Lin Chia-Hung Kao Association between Cervical Spondylosis and Migraine: A Nationwide Retrospective Cohort Study International Journal of Environmental Research and Public Health cervical spondylosis migraine retrospective cohort study population-based |
author_facet |
Wang-Sheng Lin Tung-Fu Huang Tien-Yow Chuang Cheng-Li Lin Chia-Hung Kao |
author_sort |
Wang-Sheng Lin |
title |
Association between Cervical Spondylosis and Migraine: A Nationwide Retrospective Cohort Study |
title_short |
Association between Cervical Spondylosis and Migraine: A Nationwide Retrospective Cohort Study |
title_full |
Association between Cervical Spondylosis and Migraine: A Nationwide Retrospective Cohort Study |
title_fullStr |
Association between Cervical Spondylosis and Migraine: A Nationwide Retrospective Cohort Study |
title_full_unstemmed |
Association between Cervical Spondylosis and Migraine: A Nationwide Retrospective Cohort Study |
title_sort |
association between cervical spondylosis and migraine: a nationwide retrospective cohort study |
publisher |
MDPI AG |
series |
International Journal of Environmental Research and Public Health |
issn |
1660-4601 |
publishDate |
2018-03-01 |
description |
Background: Few studies have investigated the longitudinal association between cervical spondylosis (CS) and migraine by using a nationwide population-based database. Methods: We conducted a retrospective cohort study from 2000 to 2011 identifying 27,930 cases of cervical spondylosis and 111,720 control subjects (those without cervical spondylosis) from a single database. The subjects were frequency-matched on the basis of sex, age, and diagnosis date. The non- cervical spondylosis cohort was four times the size of the cervical spondylosis cohort. To quantify the effects of cervical spondylosis on the risk of migraine, univariate and multivariate Cox proportional hazard regression analyses were used to calculate the hazard ratio (HR), and 95% confidence interval (CI). Results: After a 10-year follow-up controlling for potential confounding factors, overall migraine incidence was higher in the cervical spondylosis cohort than in the non-cervical spondylosis cohort (5.16 and 2.09 per 1000 people per year, respectively; crude hazard ratio = 2.48, 95% confidence interval = 2.28–2.69), with an adjusted hazard ratio of 2.03 (95% confidence interval = 1.86–2.22) after accounting for sex, age, comorbidities, and medication. Individuals with myelopathy in the cervical spondylosis cohort had a 2.19 times (95% confidence interval = 1.80–2.66) higher incidence of migraine when compared than did those in the non- cervical spondylosis cohort. Conclusions: Individuals with cervical spondylosis exhibited a higher risk of migraine than those without cervical spondylosis. The migraine incidence rate was even higher among individuals with cervical spondylotic myelopathy. |
topic |
cervical spondylosis migraine retrospective cohort study population-based |
url |
http://www.mdpi.com/1660-4601/15/4/587 |
work_keys_str_mv |
AT wangshenglin associationbetweencervicalspondylosisandmigraineanationwideretrospectivecohortstudy AT tungfuhuang associationbetweencervicalspondylosisandmigraineanationwideretrospectivecohortstudy AT tienyowchuang associationbetweencervicalspondylosisandmigraineanationwideretrospectivecohortstudy AT chenglilin associationbetweencervicalspondylosisandmigraineanationwideretrospectivecohortstudy AT chiahungkao associationbetweencervicalspondylosisandmigraineanationwideretrospectivecohortstudy |
_version_ |
1725399510265364480 |