Is it time to change the reference genome?
Abstract The use of the human reference genome has shaped methods and data across modern genomics. This has offered many benefits while creating a few constraints. In the following opinion, we outline the history, properties, and pitfalls of the current human reference genome. In a few illustrative...
Main Authors: | Sara Ballouz, Alexander Dobin, Jesse A. Gillis |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2019-08-01
|
Series: | Genome Biology |
Online Access: | http://link.springer.com/article/10.1186/s13059-019-1774-4 |
Similar Items
-
AuPairWise: A Method to Estimate RNA-Seq Replicability through Co-expression.
by: Sara Ballouz, et al.
Published: (2016-04-01) -
Strength of functional signature correlates with effect size in autism
by: Sara Ballouz, et al.
Published: (2017-07-01) -
Characterizing the replicability of cell types defined by single cell RNA-sequencing data using MetaNeighbor
by: Megan Crow, et al.
Published: (2018-02-01) -
Ligand Similarity Complements Sequence, Physical Interaction, and Co-Expression for Gene Function Prediction.
by: Matthew J O'Meara, et al.
Published: (2016-01-01) -
Conditions for the evolution of gene clusters in bacterial genomes.
by: Sara Ballouz, et al.
Published: (2010-02-01)