V3 loop sequence space analysis suggests different evolutionary patterns of CCR5- and CXCR4-tropic HIV.
The V3 loop of human immunodeficiency virus type 1 (HIV-1) is critical for coreceptor binding and is the main determinant of which of the cellular coreceptors, CCR5 or CXCR4, the virus uses for cell entry. The aim of this study is to provide a large-scale data driven analysis of HIV-1 coreceptor usa...
Main Authors: | Katarzyna Bozek, Alexander Thielen, Saleta Sierra, Rolf Kaiser, Thomas Lengauer |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2009-10-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2754612?pdf=render |
Similar Items
-
Analysis of physicochemical and structural properties determining HIV-1 coreceptor usage.
by: Katarzyna Bozek, et al.
Published: (2013-01-01) -
Growth potentials of CCR5-tropic/CXCR4-tropic HIV-1mt clones in macaque cells
by: Naoya eDoi, et al.
Published: (2013-07-01) -
CXCR4- and CCR5-Tropic HIV-1 Clones Are Both Tractable to Grow in Rhesus Macaques
by: Naoya Doi, et al.
Published: (2018-10-01) -
An expanded model of HIV cell entry phenotype based on multi-parameter single-cell data
by: Bozek Katarzyna, et al.
Published: (2012-07-01) -
Detection of inferred CCR5- and CXCR4-using HIV-1 variants and evolutionary intermediates using ultra-deep pyrosequencing.
by: Evelien M Bunnik, et al.
Published: (2011-06-01)