Porcine Dendritic Cells and Viruses: An Update

• Main Authors: Giulia Franzoni, Simon P. Graham, Silvia Dei Giudici, Annalisa Oggiano
• Format: Article
• Language: English
• Published: MDPI AG 2019-05-01
• Series: Viruses
• Subjects: pig; dendritic cells; ASFV; CSFV; PCV2
• Online Access: https://www.mdpi.com/1999-4915/11/5/445

Several viral infections of swine are responsible for major economic losses and represent a threat to the swine industry worldwide. New tools are needed to prevent and control endemic, emerging, and re-emerging viral diseases. Dendritic cells (DC) play a central role in linking the innate and adaptive arms of the immune system, so knowledge regarding their interaction with pathogens is necessary to understand the mechanisms underlying diseases pathogenesis and protection. In the first part of this review, we provide an update on the heterogeneous cell subsets that comprise the porcine DC family. In the second part of this review, we provide an overview of how three viruses, affecting pork production at a global level, African swine fever virus (ASFV), classical swine fever virus (CSFV), and porcine circovirus 2 (PCV2), modulate DC function.