Enterovirus and herpesviridae family as etiologic agents of lymphomonocytary meningitis, Southern Brazil

• Main Authors: Luine Rosele Renaud Vidal, Sérgio Monteiro de Almeida, Iara José de Messias-Reason, Meri Bordignon Nogueira, Maria do Carmo Debur, Luís Felipe Cavalli Pessa, Luciane Aparecida Pereira, Indianara Rotta, Gislene Reche de Almeida Takahashi, Clyete Santos da Silveira, Josianne Maria Reimann Araújo, Sonia Mara Raboni
• Format: Article
• Language: English
• Published: Academia Brasileira de Neurologia (ABNEURO) 2011-06-01
• Series: Arquivos de Neuro-Psiquiatria
• Subjects: meningite asséptica; meningite linfocítica; meningite linfomonocitária; líquido cefalorraquidiano; sistema nervoso central; enterovirus; herpesvirus
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000400013&lng=en&tlng=en
• ISSN: 1678-4227

Viral meningitis is a common infectious disease of the central nervous system (CNS) that occurs worldwide. The aim of this study was to identify the etiologic agent of lymphomonocytary meningitis in Curitiba, PR, Brazil. During the period of July 2005 to December 2006, 460 cerebrospinal fluid (CSF) samples with lymphomonocytary meningitis were analyzed by PCR methodologies. Fifty nine (12.8%) samples were positive. Enteroviruses was present in 49 (83%) samples and herpes virus family in 10 (17%), of these 6 (10%) herpes simplex virus, 1 (2%) Epstein Barr virus, 2 (3%) human herpes virus type 6 and 1 (2%) mixed infection of enterovirus and Epstein Barr virus. As conclusion enterovirus was the most frequent virus, with circulation during summer and was observed with higher frequency between 4 to 17 years of age. PCR methodology is an important method for rapid detection of RNA enterovirus and DNA herpesvirus in CSF.