Urinary Protein Creatinine Ratio in Normal Zero to Three-Day-Old Indian Neonates
Introduction: Early neonates (1-7-day-old) may develop acute kidney injury or acute renal failure due to functional (pre-renal, may be caused by decreased renal perfusion), intrinsic (renal, may be caused by acute insult), or obstructive (due to anatomic urinary tract obstruction) causes. Urinar...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
JCDR Research and Publications Private Limited
2016-03-01
|
Series: | Journal of Clinical and Diagnostic Research |
Subjects: | |
Online Access: | https://jcdr.net/articles/PDF/7442/18651_CE(RA1)_F(T)_PF1(Ru_Om)_PFA(AK)_PF2(PAG).pdf |
id |
doaj-2c383ee82fbe4491b198011867f91923 |
---|---|
record_format |
Article |
spelling |
doaj-2c383ee82fbe4491b198011867f919232020-11-25T02:23:01ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-03-01103BC21BC2310.7860/JCDR/2016/18651.7442Urinary Protein Creatinine Ratio in Normal Zero to Three-Day-Old Indian NeonatesIndu Saxena0Varun Shivankur1Manoj Kumar2Assistant Professor, Deparment of Biochemistry, AIIMS Jodhpur, Rajasthan, India. Under Graduate Student, AIIMS Jodhpur, Rajasthan, India.Professor, Department of Physiology, TMMC&RC, Moradabad, Uttar Pradesh, India.Introduction: Early neonates (1-7-day-old) may develop acute kidney injury or acute renal failure due to functional (pre-renal, may be caused by decreased renal perfusion), intrinsic (renal, may be caused by acute insult), or obstructive (due to anatomic urinary tract obstruction) causes. Urinary protein estimation is important for diagnosis, follow-up and prognosis of disease. The Protein Creatinine Ratio (PCR) has been successfully used to establish proteinuria in different types of patients. Aim: This study was undertaken to establish normal PCR range in neonates, to rule out abnormal protein excretion in sick neonates. Materials and Methods: A total of 37 normal early neonates of age 0-3 days were enrolled for this study. Random spot urine samples were collected in paediatric urine bags for protein and creatinine estimation. Results: The urinary PCR varied between 0.1-0.8. The range of PCR values obtained was greater in 0-1 day old infants, compared to infants older than one day. Changes in PCR values were due to variations in the creatinine excretion. Conclusion: Urinary PCR values ≤ 0.8 indicate normal protein excretion. However, reference intervals of PCR should be established for narrow age groups in case of early neonates, e.g. 0-6h, 6-12h, 12-24h, 24-72h old babies.https://jcdr.net/articles/PDF/7442/18651_CE(RA1)_F(T)_PF1(Ru_Om)_PFA(AK)_PF2(PAG).pdfnewbornprotein estimationproteinuria |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Indu Saxena Varun Shivankur Manoj Kumar |
spellingShingle |
Indu Saxena Varun Shivankur Manoj Kumar Urinary Protein Creatinine Ratio in Normal Zero to Three-Day-Old Indian Neonates Journal of Clinical and Diagnostic Research newborn protein estimation proteinuria |
author_facet |
Indu Saxena Varun Shivankur Manoj Kumar |
author_sort |
Indu Saxena |
title |
Urinary Protein Creatinine Ratio in Normal Zero to Three-Day-Old Indian Neonates |
title_short |
Urinary Protein Creatinine Ratio in Normal Zero to Three-Day-Old Indian Neonates |
title_full |
Urinary Protein Creatinine Ratio in Normal Zero to Three-Day-Old Indian Neonates |
title_fullStr |
Urinary Protein Creatinine Ratio in Normal Zero to Three-Day-Old Indian Neonates |
title_full_unstemmed |
Urinary Protein Creatinine Ratio in Normal Zero to Three-Day-Old Indian Neonates |
title_sort |
urinary protein creatinine ratio in normal zero to three-day-old indian neonates |
publisher |
JCDR Research and Publications Private Limited |
series |
Journal of Clinical and Diagnostic Research |
issn |
2249-782X 0973-709X |
publishDate |
2016-03-01 |
description |
Introduction: Early neonates (1-7-day-old) may develop
acute kidney injury or acute renal failure due to functional
(pre-renal, may be caused by decreased renal perfusion),
intrinsic (renal, may be caused by acute insult), or obstructive
(due to anatomic urinary tract obstruction) causes. Urinary
protein estimation is important for diagnosis, follow-up and
prognosis of disease. The Protein Creatinine Ratio (PCR) has
been successfully used to establish proteinuria in different
types of patients.
Aim: This study was undertaken to establish normal PCR
range in neonates, to rule out abnormal protein excretion in
sick neonates.
Materials and Methods: A total of 37 normal early neonates
of age 0-3 days were enrolled for this study. Random spot
urine samples were collected in paediatric urine bags for
protein and creatinine estimation.
Results: The urinary PCR varied between 0.1-0.8. The range
of PCR values obtained was greater in 0-1 day old infants,
compared to infants older than one day. Changes in PCR values
were due to variations in the creatinine excretion.
Conclusion: Urinary PCR values ≤ 0.8 indicate normal protein
excretion. However, reference intervals of PCR should be
established for narrow age groups in case of early neonates,
e.g. 0-6h, 6-12h, 12-24h, 24-72h old babies. |
topic |
newborn protein estimation proteinuria |
url |
https://jcdr.net/articles/PDF/7442/18651_CE(RA1)_F(T)_PF1(Ru_Om)_PFA(AK)_PF2(PAG).pdf |
work_keys_str_mv |
AT indusaxena urinaryproteincreatinineratioinnormalzerotothreedayoldindianneonates AT varunshivankur urinaryproteincreatinineratioinnormalzerotothreedayoldindianneonates AT manojkumar urinaryproteincreatinineratioinnormalzerotothreedayoldindianneonates |
_version_ |
1724860393924329472 |