Clinical characteristics and plasma exchange response in Guillain-Barré patients

• Main Authors: Erik Guevara-Silva, Sheila Castro-Suarez, César Caparó-Zamalloa, Jaqueline Cortez-Escalante, María Meza-Vega
• Format: Article
• Language: Spanish
• Published: Instituto Nacional de Salud 2021-03-01
• Series: Revista Peruana de Medicina Experimental y Salud Pública
• Subjects: líquido cefalorraquídeo; neuropatía axonal; neuropatía desmielinizante; poliradiculoneuropatía; plasmaféresis; perú; recambio plasmático terapéutico; síndrome de guillain-barré
• Online Access: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/6233
• ISSN: 1726-4634; 1726-4642

The objective of the study was to describe the clinical characteristics, treatment response and possible associated factors of patients with Guillain-Barré syndrome at the National Institute of Neurological Sciences. A descriptive study on hospital discharges was conducted during the period 2017-2019. Treatment response was evaluated based on Hughes’ disability scale. From 31 patients 61.3% were males and the mean age was 50 years. At admission, 87.1% of patients were on grade 3 or 4 of Hughes scale, most of them with axonal compromise which was associated to disability. Only 22 patients received plasma exchange; 6 months thereafter, 90.9% of patients decreased by at least one degree in Hughes scale and 42.8% were left without disability. In conclusion, a male and axonal subtype predominance was found, been the latter associated to disability.