Impact of Vitamin D Deficiency on COVID-19—A Prospective Analysis from the CovILD Registry
The novel Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is a global health concern. Vitamin D (VITD) deficiency has been suggested to alter SARS-CoV-2 susceptibility and the course of disease. Thus, we aimed to investigate association...
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doaj-2c395e572b874fdda0a3a942949b2d422020-11-25T02:54:22ZengMDPI AGNutrients2072-66432020-09-01122775277510.3390/nu12092775Impact of Vitamin D Deficiency on COVID-19—A Prospective Analysis from the CovILD RegistryAlex Pizzini0Magdalena Aichner1Sabina Sahanic2Anna Böhm3Alexander Egger4Gregor Hoermann5Katharina Kurz6Gerlig Widmann7Rosa Bellmann-Weiler8Günter Weiss9Ivan Tancevski10Thomas Sonnweber11Judith Löffler-Ragg12Department of Internal Medicine II, Infectious Diseases, Pneumology, Rheumatology, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Internal Medicine II, Infectious Diseases, Pneumology, Rheumatology, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Internal Medicine II, Infectious Diseases, Pneumology, Rheumatology, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Internal Medicine II, Infectious Diseases, Pneumology, Rheumatology, Medical University of Innsbruck, 6020 Innsbruck, AustriaCentral Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Innsbruck, 6020 Innsbruck, AustriaCentral Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Internal Medicine II, Infectious Diseases, Pneumology, Rheumatology, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Radiology, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Internal Medicine II, Infectious Diseases, Pneumology, Rheumatology, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Internal Medicine II, Infectious Diseases, Pneumology, Rheumatology, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Internal Medicine II, Infectious Diseases, Pneumology, Rheumatology, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Internal Medicine II, Infectious Diseases, Pneumology, Rheumatology, Medical University of Innsbruck, 6020 Innsbruck, AustriaDepartment of Internal Medicine II, Infectious Diseases, Pneumology, Rheumatology, Medical University of Innsbruck, 6020 Innsbruck, AustriaThe novel Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is a global health concern. Vitamin D (VITD) deficiency has been suggested to alter SARS-CoV-2 susceptibility and the course of disease. Thus, we aimed to investigate associations of VITD status to disease presentation within the CovILD registry. This prospective, multicenter, observational study on long-term sequelae includes patients with COVID-19 after hospitalization or outpatients with persistent symptoms. Eight weeks after PCR confirmed diagnosis, a detailed questionnaire, a clinical examination, and laboratory testing, including VITD status, were evaluated. Furthermore, available laboratory specimens close to hospital admission were used to retrospectively analyze 25-hydroxyvitamin D levels at disease onset. A total of 109 patients were included in the analysis (60% males, 40% females), aged 58 ± 14 years. Eight weeks after the onset of COVID-19, a high proportion of patients presented with impaired VITD metabolism and elevated parathyroid hormone (PTH) levels. PTH concentrations were increased in patients who needed intensive care unit (ICU) treatment, while VITD levels were not significantly different between disease severity groups. Low VITD levels at disease onset or at eight-week follow-up were not related to persistent symptom burden, lung function impairment, ongoing inflammation, or more severe CT abnormalities. VITD deficiency is frequent among COVID-19 patients but not associated with disease outcomes. However, individuals with severe disease display a disturbed parathyroid-vitamin-D axis within their recovery phase. The proposed significance of VITD supplementation in the clinical management of COVID-19 remains elusive.https://www.mdpi.com/2072-6643/12/9/2775vitamin DVITDCOVID-19SARS-CoV-2PTHparathyroid hormone |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alex Pizzini Magdalena Aichner Sabina Sahanic Anna Böhm Alexander Egger Gregor Hoermann Katharina Kurz Gerlig Widmann Rosa Bellmann-Weiler Günter Weiss Ivan Tancevski Thomas Sonnweber Judith Löffler-Ragg |
spellingShingle |
Alex Pizzini Magdalena Aichner Sabina Sahanic Anna Böhm Alexander Egger Gregor Hoermann Katharina Kurz Gerlig Widmann Rosa Bellmann-Weiler Günter Weiss Ivan Tancevski Thomas Sonnweber Judith Löffler-Ragg Impact of Vitamin D Deficiency on COVID-19—A Prospective Analysis from the CovILD Registry Nutrients vitamin D VITD COVID-19 SARS-CoV-2 PTH parathyroid hormone |
author_facet |
Alex Pizzini Magdalena Aichner Sabina Sahanic Anna Böhm Alexander Egger Gregor Hoermann Katharina Kurz Gerlig Widmann Rosa Bellmann-Weiler Günter Weiss Ivan Tancevski Thomas Sonnweber Judith Löffler-Ragg |
author_sort |
Alex Pizzini |
title |
Impact of Vitamin D Deficiency on COVID-19—A Prospective Analysis from the CovILD Registry |
title_short |
Impact of Vitamin D Deficiency on COVID-19—A Prospective Analysis from the CovILD Registry |
title_full |
Impact of Vitamin D Deficiency on COVID-19—A Prospective Analysis from the CovILD Registry |
title_fullStr |
Impact of Vitamin D Deficiency on COVID-19—A Prospective Analysis from the CovILD Registry |
title_full_unstemmed |
Impact of Vitamin D Deficiency on COVID-19—A Prospective Analysis from the CovILD Registry |
title_sort |
impact of vitamin d deficiency on covid-19—a prospective analysis from the covild registry |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2020-09-01 |
description |
The novel Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is a global health concern. Vitamin D (VITD) deficiency has been suggested to alter SARS-CoV-2 susceptibility and the course of disease. Thus, we aimed to investigate associations of VITD status to disease presentation within the CovILD registry. This prospective, multicenter, observational study on long-term sequelae includes patients with COVID-19 after hospitalization or outpatients with persistent symptoms. Eight weeks after PCR confirmed diagnosis, a detailed questionnaire, a clinical examination, and laboratory testing, including VITD status, were evaluated. Furthermore, available laboratory specimens close to hospital admission were used to retrospectively analyze 25-hydroxyvitamin D levels at disease onset. A total of 109 patients were included in the analysis (60% males, 40% females), aged 58 ± 14 years. Eight weeks after the onset of COVID-19, a high proportion of patients presented with impaired VITD metabolism and elevated parathyroid hormone (PTH) levels. PTH concentrations were increased in patients who needed intensive care unit (ICU) treatment, while VITD levels were not significantly different between disease severity groups. Low VITD levels at disease onset or at eight-week follow-up were not related to persistent symptom burden, lung function impairment, ongoing inflammation, or more severe CT abnormalities. VITD deficiency is frequent among COVID-19 patients but not associated with disease outcomes. However, individuals with severe disease display a disturbed parathyroid-vitamin-D axis within their recovery phase. The proposed significance of VITD supplementation in the clinical management of COVID-19 remains elusive. |
topic |
vitamin D VITD COVID-19 SARS-CoV-2 PTH parathyroid hormone |
url |
https://www.mdpi.com/2072-6643/12/9/2775 |
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