Th17 Polarization under Hypoxia Results in Increased IL-10 Production in a Pathogen-Independent Manner

Th17 Polarization under Hypoxia Results in Increased IL-10 Production in a Pathogen-Independent Manner

The IL-17-producing CD4+ T helper cell (Th17) differentiation is affected by stimulation of the aryl hydrocarbon receptor (AhR) pathway and by hypoxia-inducible factor 1 alpha (HIF-1α). In some cases, Th17 become non-pathogenic and produce IL-10. However, the initiating events triggering this phenot...

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Bibliographic Details
Main Authors: Roman Volchenkov, Vegard Nygaard, Zeynep Sener, Bjørn Steen Skålhegg
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Immunology
Subjects:
Th17 cells
IL-17
oxygen
cigarette smoke
aryl hydrocarbon receptor
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00698/full

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