Antioxidant, antifungal and anticancer activities of se-enriched Pleurotus spp. mycelium extracts
The goal of this study was the evaluation of antifungal, antioxidant and anticancer potentials of Pleurotus eryngii, P. ostreatus and P. pulmonarius mycelial extracts, and the influence of mycelium enrichment with selenium on these activities. Both Se-amended and non-amended extracts showed...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
University of Belgrade, University of Novi Sad
2014-01-01
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Series: | Archives of Biological Sciences |
Subjects: | |
Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2014/0354-46641404379M.pdf |
Summary: | The goal of this study was the evaluation of antifungal, antioxidant and
anticancer potentials of Pleurotus eryngii, P. ostreatus and P. pulmonarius
mycelial extracts, and the influence of mycelium enrichment with selenium on
these activities. Both Se-amended and non-amended extracts showed the same
or similar minimal inhibitory concentration for 14 studied micromycetes,
while a fungicidal effect was not noted, contrary to ketoconazole, which had
inhibitory and fungicidal effects at very low concentrations. Se-non-amended
extracts exhibited antioxidant activity, especially at higher
concentrations. Selenium enrichment influenced activity, its effects
decreasing in P. eryngii and P. pulmonarius, while in P. ostreatus no effect
was noted. The DPPH• radical scavenging capacity of the extracts was in
direct correlation with their phenol and flavonoid contents. Cytotoxic
activity against both HeLa and LS174 cell lines was very low compared with
cis-DDP. These features suggest that mycelium should be an object of
intensive studies. [Projekat Ministarstva nauke Republike Srbije, br. 173032] |
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ISSN: | 0354-4664 1821-4339 |