Membrane protein-chimeric liposome-mediated delivery of triptolide for targeted hepatocellular carcinoma therapy

Membrane protein-chimeric liposome-mediated delivery of triptolide for targeted hepatocellular carcinoma therapy

Triptolide (TPL) is a diterpenoid triepoxide with broad antitumor efficacy, while lack of mechanism of action, severe systemic toxicity, and poor water solubility of TPL limited its usage. To unveil the mechanism of action and improve the pharmaceutical properties of TPL, here we explored the molecu...

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Bibliographic Details
Main Authors:	Yanwen Zheng, Fanhua Kong, Songyang Liu, Xi Liu, Dongni Pei, Xiongying Miao
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2021-01-01
Series:	Drug Delivery
Subjects:	triptolide hepatocellular carcinoma drug delivery membrane proteins apoptosis necroptosis
Online Access:	http://dx.doi.org/10.1080/10717544.2021.1983072

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