Raised Plasma Neurofilament Light Protein Levels Are Associated with Abnormal MRI Outcomes in Newborns Undergoing Therapeutic Hypothermia

Raised Plasma Neurofilament Light Protein Levels Are Associated with Abnormal MRI Outcomes in Newborns Undergoing Therapeutic Hypothermia

Aims and hypothesisHypoxic-ischemic encephalopathy (HIE) remains an important cause of death and disability in newborns. Mild therapeutic hypothermia (TH) is safe and effective; however, there are no tissue biomarkers available at the bedside to select babies for treatment. The aim of this study was...

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Bibliographic Details
Main Authors: Divyen K. Shah, Vennila Ponnusamy, Jane Evanson, Olga Kapellou, Georgia Ekitzidou, Neelam Gupta, Paul Clarke, Adina T. Michael-Titus, Ping K. Yip
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Neurology
Subjects:
neurofilament proteins
hypoxic-ischemic encephalopathy
therapeutic hypothermia
MRI imaging
neuroprotection
biomarkers
Online Access:http://journal.frontiersin.org/article/10.3389/fneur.2018.00086/full

Internet

http://journal.frontiersin.org/article/10.3389/fneur.2018.00086/full

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