Clinical and genetic analysis of four Taiwanese families with autosomal dominant hereditary spastic paraplegia

Clinical and genetic analysis of four Taiwanese families with autosomal dominant hereditary spastic paraplegia

Hereditary spastic paraplegias (HSPs) are clinically and genetically heterogeneous neurodegenerative disorders. Defects in the SPG4 and SPG3A genes are the two leading causes of HSPs with autosomal dominant inheritance (AD-HSPs). The purpose of this study was to investigate the clinical features and...

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Bibliographic Details
Main Authors: Min-Yu Lan, Ser-Chen Fu, Yung-Yee Chang, Yah-Huei Wu-Chou, Szu-Chia Lai, Rou-Shyan Chen, Chin-Song Lu
Format: Article
Language:English
Published: Elsevier 2012-07-01
Series:Journal of the Formosan Medical Association
Subjects:
hereditary spastic paraplegia
multiplex ligation-dependent probe amplification
SPG4
spastin
Online Access:http://www.sciencedirect.com/science/article/pii/S0929664612000599

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