Metabolomic Links between Sugar-Sweetened Beverage Intake and Obesity

Background. Sugar-sweetened beverage (SSB) consumption is highly associated with obesity, but the metabolic mechanism underlying this correlation is not understood. Objective. Our objective was to examine metabolomic links between SSB intake and obesity to understand metabolic mechanisms. Design. We...

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Main Authors: Bingjie Zhou, Reiko Ichikawa, Laurence D. Parnell, Sabrina E. Noel, Xiyuan Zhang, Shilpa N. Bhupathiraju, Caren E. Smith, Katherine L. Tucker, Jose M. Ordovas, Chao-Qiang Lai
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:Journal of Obesity
Online Access:http://dx.doi.org/10.1155/2020/7154738
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spelling doaj-2c88b98ac8064c9abc3ba56b1d550cde2020-11-25T03:10:25ZengHindawi LimitedJournal of Obesity2090-07082090-07162020-01-01202010.1155/2020/71547387154738Metabolomic Links between Sugar-Sweetened Beverage Intake and ObesityBingjie Zhou0Reiko Ichikawa1Laurence D. Parnell2Sabrina E. Noel3Xiyuan Zhang4Shilpa N. Bhupathiraju5Caren E. Smith6Katherine L. Tucker7Jose M. Ordovas8Chao-Qiang Lai9Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USANutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USAUSDA Agricultural Research Service, Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USADepartment of Biomedical and Nutritional Sciences, University of Massachusetts Lowell, Lowell, MA, USADepartment of Biomedical and Nutritional Sciences, University of Massachusetts Lowell, Lowell, MA, USAChanning Division of Network Medicine, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USANutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USADepartment of Biomedical and Nutritional Sciences, University of Massachusetts Lowell, Lowell, MA, USANutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USAUSDA Agricultural Research Service, Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USABackground. Sugar-sweetened beverage (SSB) consumption is highly associated with obesity, but the metabolic mechanism underlying this correlation is not understood. Objective. Our objective was to examine metabolomic links between SSB intake and obesity to understand metabolic mechanisms. Design. We examined the association of plasma metabolomic profiles with SSB intake and obesity risk in 781 participants, aged 45–75 y, in the Boston Puerto Rican Health Study (BPRHS) using generalized linear models, controlling for potential confounding factors. Based on identified metabolites, we conducted pathway enrichment analysis to identify potential metabolic pathways that link SSB intake and obesity risk. Variants in genes encoding enzymes known to function in identified metabolic pathways were examined for their interactions with SSB intake on obesity. Results. SSB intake was correlated with BMI (β = 0.607, P=0.045). Among 526 measured metabolites, 86 showed a significant correlation with SSB intake and 148 with BMI (P≤0.05); 28 were correlated with both SSB intake and BMI (P≤0.05). Pathway enrichment analysis identified the phosphatidylcholine and lysophospholipid pathways as linking SSB intake to obesity, after correction for multiple testing. Furthermore, 8 of 10 genes functioning in these two pathways showed strong interaction with SSB intake on BMI. Our results further identified participants who may exhibit an increased risk of obesity when consuming SSB. Conclusions. We identified two key metabolic pathways that link SSB intake to obesity, revealing the potential of phosphatidylcholine and lysophospholipid to modulate how SSB intake can increase obesity risk. The interaction between genetic variants related to these pathways and SSB intake on obesity further supports the mechanism.http://dx.doi.org/10.1155/2020/7154738
collection DOAJ
language English
format Article
sources DOAJ
author Bingjie Zhou
Reiko Ichikawa
Laurence D. Parnell
Sabrina E. Noel
Xiyuan Zhang
Shilpa N. Bhupathiraju
Caren E. Smith
Katherine L. Tucker
Jose M. Ordovas
Chao-Qiang Lai
spellingShingle Bingjie Zhou
Reiko Ichikawa
Laurence D. Parnell
Sabrina E. Noel
Xiyuan Zhang
Shilpa N. Bhupathiraju
Caren E. Smith
Katherine L. Tucker
Jose M. Ordovas
Chao-Qiang Lai
Metabolomic Links between Sugar-Sweetened Beverage Intake and Obesity
Journal of Obesity
author_facet Bingjie Zhou
Reiko Ichikawa
Laurence D. Parnell
Sabrina E. Noel
Xiyuan Zhang
Shilpa N. Bhupathiraju
Caren E. Smith
Katherine L. Tucker
Jose M. Ordovas
Chao-Qiang Lai
author_sort Bingjie Zhou
title Metabolomic Links between Sugar-Sweetened Beverage Intake and Obesity
title_short Metabolomic Links between Sugar-Sweetened Beverage Intake and Obesity
title_full Metabolomic Links between Sugar-Sweetened Beverage Intake and Obesity
title_fullStr Metabolomic Links between Sugar-Sweetened Beverage Intake and Obesity
title_full_unstemmed Metabolomic Links between Sugar-Sweetened Beverage Intake and Obesity
title_sort metabolomic links between sugar-sweetened beverage intake and obesity
publisher Hindawi Limited
series Journal of Obesity
issn 2090-0708
2090-0716
publishDate 2020-01-01
description Background. Sugar-sweetened beverage (SSB) consumption is highly associated with obesity, but the metabolic mechanism underlying this correlation is not understood. Objective. Our objective was to examine metabolomic links between SSB intake and obesity to understand metabolic mechanisms. Design. We examined the association of plasma metabolomic profiles with SSB intake and obesity risk in 781 participants, aged 45–75 y, in the Boston Puerto Rican Health Study (BPRHS) using generalized linear models, controlling for potential confounding factors. Based on identified metabolites, we conducted pathway enrichment analysis to identify potential metabolic pathways that link SSB intake and obesity risk. Variants in genes encoding enzymes known to function in identified metabolic pathways were examined for their interactions with SSB intake on obesity. Results. SSB intake was correlated with BMI (β = 0.607, P=0.045). Among 526 measured metabolites, 86 showed a significant correlation with SSB intake and 148 with BMI (P≤0.05); 28 were correlated with both SSB intake and BMI (P≤0.05). Pathway enrichment analysis identified the phosphatidylcholine and lysophospholipid pathways as linking SSB intake to obesity, after correction for multiple testing. Furthermore, 8 of 10 genes functioning in these two pathways showed strong interaction with SSB intake on BMI. Our results further identified participants who may exhibit an increased risk of obesity when consuming SSB. Conclusions. We identified two key metabolic pathways that link SSB intake to obesity, revealing the potential of phosphatidylcholine and lysophospholipid to modulate how SSB intake can increase obesity risk. The interaction between genetic variants related to these pathways and SSB intake on obesity further supports the mechanism.
url http://dx.doi.org/10.1155/2020/7154738
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