AKT1low quiescent cancer cells persist after neoadjuvant chemotherapy in triple negative breast cancer

AKT1low quiescent cancer cells persist after neoadjuvant chemotherapy in triple negative breast cancer

Abstract Background Absence of pathologic complete response (pCR) to neoadjuvant chemotherapy (NACT) correlates with poor long-term survival in patients with triple negative breast cancer (TNBC). These incomplete treatment responses are likely determined by mechanisms that enable cancer cells to res...

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Bibliographic Details
Main Authors: Sheheryar Kabraji, Xavier Solé, Ying Huang, Clyde Bango, Michaela Bowden, Aditya Bardia, Dennis Sgroi, Massimo Loda, Sridhar Ramaswamy
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Breast Cancer Research
Subjects:
AKT1low quiescent cancer cells
Chemotherapy resistance
Quantitative immunofluorescence microscopy
Online Access:http://link.springer.com/article/10.1186/s13058-017-0877-7

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