Lactobacillus paracasei PS23 Delays Progression of Age-Related Cognitive Decline in Senescence Accelerated Mouse Prone 8 (SAMP8) Mice
Probiotic supplements are potential therapeutic agents for age-related disorders due to their antioxidant and anti-inflammatory properties. However, the effect of probiotics on age-related brain dysfunction remains unclear. To investigate the effects of Lactobacillus paracasei PS23 (LPPS23) on the p...
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doaj-2c9031beefa746e2b354ba1e9d9bddbd2020-11-24T20:53:34ZengMDPI AGNutrients2072-66432018-07-0110789410.3390/nu10070894nu10070894Lactobacillus paracasei PS23 Delays Progression of Age-Related Cognitive Decline in Senescence Accelerated Mouse Prone 8 (SAMP8) MiceShih-Yi Huang0Li-Han Chen1Ming-Fu Wang2Chih-Chieh Hsu3Ching-Hung Chan4Jia-Xian Li5Hui-Yu Huang6Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei 11031, TaiwanDepartment of Food Science, Nutrition, and Nutraceutical Biotechnology, Shih Chien University, Taipei 10462, TaiwanDepartment of Food and Nutrition, Providence University, Taichung 43301, TaiwanBiomedical Co., Ltd., Taipei 10448, TaiwanDepartment of Food Science, Nutrition, and Nutraceutical Biotechnology, Shih Chien University, Taipei 10462, TaiwanDepartment of Food Science, Nutrition, and Nutraceutical Biotechnology, Shih Chien University, Taipei 10462, TaiwanGraduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei 11031, TaiwanProbiotic supplements are potential therapeutic agents for age-related disorders due to their antioxidant and anti-inflammatory properties. However, the effect of probiotics on age-related brain dysfunction remains unclear. To investigate the effects of Lactobacillus paracasei PS23 (LPPS23) on the progression of age-related cognitive decline, male and female senescence-accelerated mouse prone 8 (SAMP8) mice were divided into two groups (n = 6 each): the control and PS23 groups. From the age of 16 weeks, these groups were given saline and LPPS23, respectively, because SAMP8 mice start aging rapidly after four months of age. After 12 weeks of treatment, we evaluated the effect of LPPS23 by analyzing their appearance, behavior, neural monoamines, anti-oxidative enzymes, and inflammatory cytokines. The PS23 group showed lower scores of senescence and less serious anxiety-like behaviors and memory impairment compared to the control group. The control mice also showed lower levels of neural monoamines in the striatum, hippocampus, and serum. Moreover, LPPS23 induced the anti-oxidative enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx). Higher levels of tumor necrosis factor (TNF)-α and monocyte chemotactic protein-1 (MCP1) and lower levels of interleukin (IL)-10 indicated that LPPS23 modulated the inflammation. Our results suggest that LPPS23 supplements could delay age-related cognitive decline, possibly by preventing oxidation and inflammation and modulating gut–brain axis communication.http://www.mdpi.com/2072-6643/10/7/894agingsenescence-accelerated mouse prone 8 (SAMP8)Lactobacillus paracasei PS23cognitive impairment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shih-Yi Huang Li-Han Chen Ming-Fu Wang Chih-Chieh Hsu Ching-Hung Chan Jia-Xian Li Hui-Yu Huang |
spellingShingle |
Shih-Yi Huang Li-Han Chen Ming-Fu Wang Chih-Chieh Hsu Ching-Hung Chan Jia-Xian Li Hui-Yu Huang Lactobacillus paracasei PS23 Delays Progression of Age-Related Cognitive Decline in Senescence Accelerated Mouse Prone 8 (SAMP8) Mice Nutrients aging senescence-accelerated mouse prone 8 (SAMP8) Lactobacillus paracasei PS23 cognitive impairment |
author_facet |
Shih-Yi Huang Li-Han Chen Ming-Fu Wang Chih-Chieh Hsu Ching-Hung Chan Jia-Xian Li Hui-Yu Huang |
author_sort |
Shih-Yi Huang |
title |
Lactobacillus paracasei PS23 Delays Progression of Age-Related Cognitive Decline in Senescence Accelerated Mouse Prone 8 (SAMP8) Mice |
title_short |
Lactobacillus paracasei PS23 Delays Progression of Age-Related Cognitive Decline in Senescence Accelerated Mouse Prone 8 (SAMP8) Mice |
title_full |
Lactobacillus paracasei PS23 Delays Progression of Age-Related Cognitive Decline in Senescence Accelerated Mouse Prone 8 (SAMP8) Mice |
title_fullStr |
Lactobacillus paracasei PS23 Delays Progression of Age-Related Cognitive Decline in Senescence Accelerated Mouse Prone 8 (SAMP8) Mice |
title_full_unstemmed |
Lactobacillus paracasei PS23 Delays Progression of Age-Related Cognitive Decline in Senescence Accelerated Mouse Prone 8 (SAMP8) Mice |
title_sort |
lactobacillus paracasei ps23 delays progression of age-related cognitive decline in senescence accelerated mouse prone 8 (samp8) mice |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2018-07-01 |
description |
Probiotic supplements are potential therapeutic agents for age-related disorders due to their antioxidant and anti-inflammatory properties. However, the effect of probiotics on age-related brain dysfunction remains unclear. To investigate the effects of Lactobacillus paracasei PS23 (LPPS23) on the progression of age-related cognitive decline, male and female senescence-accelerated mouse prone 8 (SAMP8) mice were divided into two groups (n = 6 each): the control and PS23 groups. From the age of 16 weeks, these groups were given saline and LPPS23, respectively, because SAMP8 mice start aging rapidly after four months of age. After 12 weeks of treatment, we evaluated the effect of LPPS23 by analyzing their appearance, behavior, neural monoamines, anti-oxidative enzymes, and inflammatory cytokines. The PS23 group showed lower scores of senescence and less serious anxiety-like behaviors and memory impairment compared to the control group. The control mice also showed lower levels of neural monoamines in the striatum, hippocampus, and serum. Moreover, LPPS23 induced the anti-oxidative enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx). Higher levels of tumor necrosis factor (TNF)-α and monocyte chemotactic protein-1 (MCP1) and lower levels of interleukin (IL)-10 indicated that LPPS23 modulated the inflammation. Our results suggest that LPPS23 supplements could delay age-related cognitive decline, possibly by preventing oxidation and inflammation and modulating gut–brain axis communication. |
topic |
aging senescence-accelerated mouse prone 8 (SAMP8) Lactobacillus paracasei PS23 cognitive impairment |
url |
http://www.mdpi.com/2072-6643/10/7/894 |
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