AtrR Is an Essential Determinant of Azole Resistance in Aspergillus fumigatus

AtrR Is an Essential Determinant of Azole Resistance in Aspergillus fumigatus

Aspergillus fumigatus is the major filamentous fungal pathogen in humans. Infections associated with A. fumigatus are often treated with azole drugs, but resistance to these antifungal agents is increasing. Mortality from aspergillosis associated with azole-resistant fungi is extremely high. Previou...

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Bibliographic Details
Main Authors: Sanjoy Paul, Mark Stamnes, Grace Heredge Thomas, Hong Liu, Daisuke Hagiwara, Katsuya Gomi, Scott G. Filler, W. Scott Moye-Rowley
Format: Article
Language:English
Published: American Society for Microbiology 2019-03-01
Series:mBio
Subjects:
ABC transporters
antifungal resistance
Aspergillus fumigatus
molecular genetics
transcriptional regulation
Online Access:https://doi.org/10.1128/mBio.02563-18

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