The Involvement of the RhoA/ROCK Signaling Pathway in Hypersensitivity Reactions Induced by Paclitaxel Injection

The Involvement of the RhoA/ROCK Signaling Pathway in Hypersensitivity Reactions Induced by Paclitaxel Injection

A high incidence of hypersensitivity reactions (HSRs) largely limits the use of paclitaxel injection. Currently, these reactions are considered to be mediated by histamine release and complement activation. However, the evidence is insufficient and the molecular mechanism involved in paclitaxel inje...

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Bibliographic Details
Main Authors: Chen Pan, Yu-Shi Zhang, Jia-Yin Han, Chun-Ying Li, Yan Yi, Yong Zhao, Lian-Mei Wang, Jing-Zhuo Tian, Su-Yan Liu, Gui-Qin Li, Xiao-Long Li, Zhong Xian, Ai-Hua Liang
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
paclitaxel injection
hypersensitivity reactions
vascular permeability
histamine release
complement activation
rhoa/rock signaling pathway
Online Access:https://www.mdpi.com/1422-0067/20/20/4988

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https://www.mdpi.com/1422-0067/20/20/4988

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