Chagasic thymic atrophy does not affect negative selection but results in the export of activated CD4+CD8+ T cells in severe forms of human disease.

Chagasic thymic atrophy does not affect negative selection but results in the export of activated CD4+CD8+ T cells in severe forms of human disease.

Extrathymic CD4+CD8+ double-positive (DP) T cells are increased in some pathophysiological conditions, including infectious diseases. In the murine model of Chagas disease, it has been shown that the protozoan parasite Trypanosoma cruzi is able to target the thymus and induce alterations of the thym...

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Main Authors: Alexandre Morrot, Eugênia Terra-Granado, Ana Rosa Pérez, Suse Dayse Silva-Barbosa, Novica M Milićević, Désio Aurélio Farias-de-Oliveira, Luiz Ricardo Berbert, Juliana De Meis, Christina Maeda Takiya, Juan Beloscar, Xiaoping Wang, Vivian Kont, Pärt Peterson, Oscar Bottasso, Wilson Savino
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-08-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3156684?pdf=render

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