The effects of vitamin D and omega-3 fatty acids co-supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in patients with gestational diabetes
Abstract Background This study was carried out to determine the effects of vitamin D and omega-3 fatty acids co- supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes (GDM) patients. Methods This randomized, double-blind, placebo-controlled tr...
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doaj-2cceb5440fb14cc1b3e1f72ac5c45df42020-11-25T01:04:20ZengBMCNutrition & Metabolism1743-70752017-12-011411910.1186/s12986-017-0236-9The effects of vitamin D and omega-3 fatty acids co-supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in patients with gestational diabetesMaryamalsadat Razavi0Mehri Jamilian1Mansooreh Samimi2Faraneh Afshar Ebrahimi3Mohsen Taghizadeh4Reza Bekhradi5Elahe Seyed Hosseini6Hamed Haddad Kashani7Maryam Karamali8Zatollah Asemi9Department of Gynecology and Obstetrics, School of Medicine, Ardabil University of Medical SciencesEndocrinology and Metabolism Research Center, Department of Gynecology and Obstetrics, School of Medicine, Arak University of Medical SciencesDepartment of Gynecology and Obstetrics, School of Medicine, Kashan University of Medical SciencesDepartment of Gynecology and Obstetrics, School of Medicine, Kashan University of Medical SciencesResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical SciencesBarij Medicinal Plants Research CenterAnatomical Sciences Research Center, Kashan University of Medical SciencesAnatomical Sciences Research Center, Kashan University of Medical SciencesDepartment of Gynecology and Obstetrics, School of Medicine, Iran University of Medical SciencesResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical SciencesAbstract Background This study was carried out to determine the effects of vitamin D and omega-3 fatty acids co- supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes (GDM) patients. Methods This randomized, double-blind, placebo-controlled trial was conducted among 120 GDM women. Participants were randomly divided into four groups to receive: 1) 1000 mg omega-3 fatty acids containing 180 mg eicosapentaenoic acid (EPA) and 120 mg docosahexaenoic acid (DHA) twice a day + vitamin D placebo (n = 30); 2) 50,000 IU vitamin D every 2 weeks + omega-3 fatty acids placebo (n = 30); 3) 50,000 IU vitamin D every 2 weeks + 1000 mg omega-3 fatty acids twice a day (n = 30) and 4) vitamin D placebo + omega-3 fatty acids placebo (n = 30) for 6 weeks. Results Subjects who received vitamin D plus omega-3 fatty acids supplements compared with vitamin D, omega-3 fatty acids and placebo had significantly decreased high-sensitivity C-reactive protein (−2.0 ± 3.3 vs. -0.8 ± 4.4, −1.3 ± 2.4 and +0.9 ± 2.7 mg/L, respectively, P = 0.008), malondialdehyde (−0.5 ± 0.5 vs. −0.2 ± 0.5, −0.3 ± 0.9 and +0.5 ± 1.4 μmol/L, respectively, P < 0.001), and increased total antioxidant capacity (+92.1 ± 70.1 vs. +55.1 ± 123.6, +88.4 ± 95.2 and +1.0 ± 90.8 mmol/L, respectively, P = 0.001) and glutathione (+95.7 ± 86.7 vs. +23.0 ± 62.3, +30.0 ± 66.5 and −7.8 ± 126.5 μmol/L, respectively, P = 0.001). In addition, vitamin D and omega-3 fatty acids co-supplementation, compared with vitamin D, omega-3 fatty acids and placebo, resulted in lower incidences of newborns’ hyperbilirubinemiain (P = 0.037) and newborns’ hospitalization (P = 0.037). Conclusion Overall, vitamin D and omega-3 fatty acids co-supplementation for 6 weeks among GDM women had beneficial effects on some biomarkers of inflammation, oxidative stress and pregnancy outcomes.http://link.springer.com/article/10.1186/s12986-017-0236-9Vitamin DOmega-3 fatty acidsSupplementationGestational diabetesPregnancy outcomes |
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language |
English |
format |
Article |
sources |
DOAJ |
author |
Maryamalsadat Razavi Mehri Jamilian Mansooreh Samimi Faraneh Afshar Ebrahimi Mohsen Taghizadeh Reza Bekhradi Elahe Seyed Hosseini Hamed Haddad Kashani Maryam Karamali Zatollah Asemi |
spellingShingle |
Maryamalsadat Razavi Mehri Jamilian Mansooreh Samimi Faraneh Afshar Ebrahimi Mohsen Taghizadeh Reza Bekhradi Elahe Seyed Hosseini Hamed Haddad Kashani Maryam Karamali Zatollah Asemi The effects of vitamin D and omega-3 fatty acids co-supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in patients with gestational diabetes Nutrition & Metabolism Vitamin D Omega-3 fatty acids Supplementation Gestational diabetes Pregnancy outcomes |
author_facet |
Maryamalsadat Razavi Mehri Jamilian Mansooreh Samimi Faraneh Afshar Ebrahimi Mohsen Taghizadeh Reza Bekhradi Elahe Seyed Hosseini Hamed Haddad Kashani Maryam Karamali Zatollah Asemi |
author_sort |
Maryamalsadat Razavi |
title |
The effects of vitamin D and omega-3 fatty acids co-supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in patients with gestational diabetes |
title_short |
The effects of vitamin D and omega-3 fatty acids co-supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in patients with gestational diabetes |
title_full |
The effects of vitamin D and omega-3 fatty acids co-supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in patients with gestational diabetes |
title_fullStr |
The effects of vitamin D and omega-3 fatty acids co-supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in patients with gestational diabetes |
title_full_unstemmed |
The effects of vitamin D and omega-3 fatty acids co-supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in patients with gestational diabetes |
title_sort |
effects of vitamin d and omega-3 fatty acids co-supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in patients with gestational diabetes |
publisher |
BMC |
series |
Nutrition & Metabolism |
issn |
1743-7075 |
publishDate |
2017-12-01 |
description |
Abstract Background This study was carried out to determine the effects of vitamin D and omega-3 fatty acids co- supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes (GDM) patients. Methods This randomized, double-blind, placebo-controlled trial was conducted among 120 GDM women. Participants were randomly divided into four groups to receive: 1) 1000 mg omega-3 fatty acids containing 180 mg eicosapentaenoic acid (EPA) and 120 mg docosahexaenoic acid (DHA) twice a day + vitamin D placebo (n = 30); 2) 50,000 IU vitamin D every 2 weeks + omega-3 fatty acids placebo (n = 30); 3) 50,000 IU vitamin D every 2 weeks + 1000 mg omega-3 fatty acids twice a day (n = 30) and 4) vitamin D placebo + omega-3 fatty acids placebo (n = 30) for 6 weeks. Results Subjects who received vitamin D plus omega-3 fatty acids supplements compared with vitamin D, omega-3 fatty acids and placebo had significantly decreased high-sensitivity C-reactive protein (−2.0 ± 3.3 vs. -0.8 ± 4.4, −1.3 ± 2.4 and +0.9 ± 2.7 mg/L, respectively, P = 0.008), malondialdehyde (−0.5 ± 0.5 vs. −0.2 ± 0.5, −0.3 ± 0.9 and +0.5 ± 1.4 μmol/L, respectively, P < 0.001), and increased total antioxidant capacity (+92.1 ± 70.1 vs. +55.1 ± 123.6, +88.4 ± 95.2 and +1.0 ± 90.8 mmol/L, respectively, P = 0.001) and glutathione (+95.7 ± 86.7 vs. +23.0 ± 62.3, +30.0 ± 66.5 and −7.8 ± 126.5 μmol/L, respectively, P = 0.001). In addition, vitamin D and omega-3 fatty acids co-supplementation, compared with vitamin D, omega-3 fatty acids and placebo, resulted in lower incidences of newborns’ hyperbilirubinemiain (P = 0.037) and newborns’ hospitalization (P = 0.037). Conclusion Overall, vitamin D and omega-3 fatty acids co-supplementation for 6 weeks among GDM women had beneficial effects on some biomarkers of inflammation, oxidative stress and pregnancy outcomes. |
topic |
Vitamin D Omega-3 fatty acids Supplementation Gestational diabetes Pregnancy outcomes |
url |
http://link.springer.com/article/10.1186/s12986-017-0236-9 |
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