Mialostatin, a Novel Midgut Cystatin from <i>Ixodes ricinus</i> Ticks: Crystal Structure and Regulation of Host Blood Digestion

Mialostatin, a Novel Midgut Cystatin from <i>Ixodes ricinus</i> Ticks: Crystal Structure and Regulation of Host Blood Digestion

The hard tick <i>Ixodes ricinus</i> is a vector of Lyme disease and tick-borne encephalitis. Host blood protein digestion, essential for tick development and reproduction, occurs in tick midgut digestive cells driven by cathepsin proteases. Little is known about the regulation of the dig...

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Bibliographic Details
Main Authors: Jan Kotál, Michal Buša, Veronika Urbanová, Pavlína Řezáčová, Jindřich Chmelař, Helena Langhansová, Daniel Sojka, Michael Mareš, Michail Kotsyfakis
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
cathepsin
crystal structure
cysteine protease
digestion
<i>Ixodes ricinus</i>
midgut
Online Access:https://www.mdpi.com/1422-0067/22/10/5371

Internet

https://www.mdpi.com/1422-0067/22/10/5371

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