Targeted deletion of Nrf2 reduces urethane-induced lung tumor development in mice.

Targeted deletion of Nrf2 reduces urethane-induced lung tumor development in mice.

Nrf2 is a key transcription factor that regulates cellular redox and defense responses. However, permanent Nrf2 activation in human lung carcinomas promotes pulmonary malignancy and chemoresistance. We tested the hypothesis that Nrf2 has cell survival properties and lack of Nrf2 suppresses chemicall...

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Bibliographic Details
Main Authors: Alison K Bauer, Hye-Youn Cho, Laura Miller-Degraff, Christopher Walker, Katherine Helms, Jennifer Fostel, Masayuki Yamamoto, Steven R Kleeberger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3198791?pdf=render

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