Prospects for improving evaluation of live tularemia vaccine quality
The article presents prospects for improving the evaluation of live tularemia vaccine (hereinafter - tularemia vaccine) quality in terms of the following parameters: «Identification», «Specific activity (the number of living microbial cells)» and the «Absence of extraneous microorganisms and fungi»....
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Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products»
2018-02-01
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Series: | Биопрепараты: Профилактика, диагностика, лечение |
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Online Access: | https://www.biopreparations.ru/jour/article/view/111 |
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doaj-2cecdd0ddc1f4030986e84c4c8fb8f732021-07-28T14:03:34ZrusMinistry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» Биопрепараты: Профилактика, диагностика, лечение2221-996X2619-11562018-02-01174240247111Prospects for improving evaluation of live tularemia vaccine qualityI. V. Kasina0S. A. Alekseeva1Z. E. Berdnikova2T. I. Nemirovskaya3A. S. Alekhina4Scientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsThe article presents prospects for improving the evaluation of live tularemia vaccine (hereinafter - tularemia vaccine) quality in terms of the following parameters: «Identification», «Specific activity (the number of living microbial cells)» and the «Absence of extraneous microorganisms and fungi». The authors investigated the possibility of improving evaluation of tularemia vaccine quality as regards the «Identification» parameter by using a commercial diagnostic test kit - immunochromatographic test system for express detection and identification of tularemia agent («F. tularensis ICA test system»). In order to optimize and improve the evaluation of tularemia vaccine quality as regards «Specific activity (the number of living microbial cells)» parameter it is recommended to use a ready-to-use growth medium for cultivation and isolation of tularemia microbe - as an additional culture medium for determination of the number of living microbial cells. It is proposed to improve the methodology of tularemia vaccine quality evaluation as regards the «Absence of foreign microorganisms and fungi» parameter by eliminating the stage of subculturing material in thioglycollate medium for 5-7 days, which is reasonable from economic and practical points of view and also reduces the risk of false positive results.https://www.biopreparations.ru/jour/article/view/111francisella tularensisвакцина туляремийная живаяподлинностьспецифическая активностьколичество живых микробных клетокfrancisella tularensislive tularemia vaccineidentificationspecific activitynumber of living microbial cellsgrowth medium for cultivation and isolation of tularemia microbe (ft agar)branch standard sample |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
I. V. Kasina S. A. Alekseeva Z. E. Berdnikova T. I. Nemirovskaya A. S. Alekhina |
spellingShingle |
I. V. Kasina S. A. Alekseeva Z. E. Berdnikova T. I. Nemirovskaya A. S. Alekhina Prospects for improving evaluation of live tularemia vaccine quality Биопрепараты: Профилактика, диагностика, лечение francisella tularensis вакцина туляремийная живая подлинность специфическая активность количество живых микробных клеток francisella tularensis live tularemia vaccine identification specific activity number of living microbial cells growth medium for cultivation and isolation of tularemia microbe (ft agar) branch standard sample |
author_facet |
I. V. Kasina S. A. Alekseeva Z. E. Berdnikova T. I. Nemirovskaya A. S. Alekhina |
author_sort |
I. V. Kasina |
title |
Prospects for improving evaluation of live tularemia vaccine quality |
title_short |
Prospects for improving evaluation of live tularemia vaccine quality |
title_full |
Prospects for improving evaluation of live tularemia vaccine quality |
title_fullStr |
Prospects for improving evaluation of live tularemia vaccine quality |
title_full_unstemmed |
Prospects for improving evaluation of live tularemia vaccine quality |
title_sort |
prospects for improving evaluation of live tularemia vaccine quality |
publisher |
Ministry of Health of the Russian Federation. Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» |
series |
Биопрепараты: Профилактика, диагностика, лечение |
issn |
2221-996X 2619-1156 |
publishDate |
2018-02-01 |
description |
The article presents prospects for improving the evaluation of live tularemia vaccine (hereinafter - tularemia vaccine) quality in terms of the following parameters: «Identification», «Specific activity (the number of living microbial cells)» and the «Absence of extraneous microorganisms and fungi». The authors investigated the possibility of improving evaluation of tularemia vaccine quality as regards the «Identification» parameter by using a commercial diagnostic test kit - immunochromatographic test system for express detection and identification of tularemia agent («F. tularensis ICA test system»). In order to optimize and improve the evaluation of tularemia vaccine quality as regards «Specific activity (the number of living microbial cells)» parameter it is recommended to use a ready-to-use growth medium for cultivation and isolation of tularemia microbe - as an additional culture medium for determination of the number of living microbial cells. It is proposed to improve the methodology of tularemia vaccine quality evaluation as regards the «Absence of foreign microorganisms and fungi» parameter by eliminating the stage of subculturing material in thioglycollate medium for 5-7 days, which is reasonable from economic and practical points of view and also reduces the risk of false positive results. |
topic |
francisella tularensis вакцина туляремийная живая подлинность специфическая активность количество живых микробных клеток francisella tularensis live tularemia vaccine identification specific activity number of living microbial cells growth medium for cultivation and isolation of tularemia microbe (ft agar) branch standard sample |
url |
https://www.biopreparations.ru/jour/article/view/111 |
work_keys_str_mv |
AT ivkasina prospectsforimprovingevaluationoflivetularemiavaccinequality AT saalekseeva prospectsforimprovingevaluationoflivetularemiavaccinequality AT zeberdnikova prospectsforimprovingevaluationoflivetularemiavaccinequality AT tinemirovskaya prospectsforimprovingevaluationoflivetularemiavaccinequality AT asalekhina prospectsforimprovingevaluationoflivetularemiavaccinequality |
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1721268673727954944 |