The short-term economic burden of gestational diabetes mellitus in Italy
Abstract Background The incidence of Gestational Diabetes Mellitus (GDM) is rising in all developed countries. This study aimed at assessing the short-term economic burden of GDM from the Italian healthcare system perspective. Methods A model was built over the last pregnancy trimester (i.e., from t...
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doaj-2cf617983b594609ba38ac29c654a6a92020-11-25T01:33:16ZengBMCBMC Pregnancy and Childbirth1471-23932018-02-011811910.1186/s12884-018-1689-1The short-term economic burden of gestational diabetes mellitus in ItalyMichela Meregaglia0Livia Dainelli1Helen Banks2Chiara Benedetto3Patrick Detzel4Giovanni Fattore5CERGAS (Centre for Research on Health and Social Care Management), Bocconi UniversityNestlé Research Center, Nestec SACERGAS (Centre for Research on Health and Social Care Management), Bocconi UniversityDepartment of Gynecology & Obstetrics, S. Anna Hospital, University of TurinNestlé Research Center, Nestec SACERGAS (Centre for Research on Health and Social Care Management), Bocconi UniversityAbstract Background The incidence of Gestational Diabetes Mellitus (GDM) is rising in all developed countries. This study aimed at assessing the short-term economic burden of GDM from the Italian healthcare system perspective. Methods A model was built over the last pregnancy trimester (i.e., from the 28th gestational week until childbirth included). The National Hospital Discharge Database (2014) was accessed to estimate delivery outcome probabilities and inpatient costs in GDM and normal pregnancies (i.e., euglycemia). International Classification of Disease-9th Revision-Clinical Modification (ICD9-CM) diagnostic codes and Diagnosis-Related Group (DRG) codes were used to identify GDM cases and different types of delivery (i.e., vaginal or cesarean) within the database. Neonatal outcomes probabilities were estimated from the literature and included macrosomia, hypoglycemia, hyperbilirubinemia, shoulder dystocia, respiratory distress, and brachial plexus injury. Additional data sources such as regional documents, official price and tariff lists, national statistics and expert opinion were used to populate the model. The average cost per case was calculated at national level to estimate the annual economic burden of GDM. One-way sensitivity analyses and Monte Carlo simulations were performed to quantify the uncertainty around base case results. Results The amount of pregnancies complicated by GDM in Italy was assessed at 54,783 in 2014 using a prevalence rate of 10.9%. The antenatal outpatient cost per case was estimated at €43.7 in normal pregnancies compared to €370.6 in GDM patients, which is equivalent to a weighted sum of insulin- (14%; €1034.6) and diet- (86%; €262.5) treated women’s costs. Inpatient delivery costs were assessed at €1601.6 and €1150.3 for euglycemic women and their infants, and at €1835.0 and €1407.7 for GDM women and their infants, respectively. Thus, the overall cost per case difference between GDM and normal pregnancies was equal to €817.8 (+ 29.2%), resulting in an economic burden of about €44.8 million in 2014 at national level. Probabilistic sensitivity analysis yielded a cost per case difference ranging between €464.9 and €1164.8 in 80% of simulations. Conclusions The economic burden of GDM in Italy is substantial even accounting for short-term medical costs only. Future research also addressing long-term consequences from a broader societal perspective is recommended.http://link.springer.com/article/10.1186/s12884-018-1689-1Gestational diabetes mellitus (GDM)Hospital discharge database (HDD)Delivery outcomesCostsItaly |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michela Meregaglia Livia Dainelli Helen Banks Chiara Benedetto Patrick Detzel Giovanni Fattore |
spellingShingle |
Michela Meregaglia Livia Dainelli Helen Banks Chiara Benedetto Patrick Detzel Giovanni Fattore The short-term economic burden of gestational diabetes mellitus in Italy BMC Pregnancy and Childbirth Gestational diabetes mellitus (GDM) Hospital discharge database (HDD) Delivery outcomes Costs Italy |
author_facet |
Michela Meregaglia Livia Dainelli Helen Banks Chiara Benedetto Patrick Detzel Giovanni Fattore |
author_sort |
Michela Meregaglia |
title |
The short-term economic burden of gestational diabetes mellitus in Italy |
title_short |
The short-term economic burden of gestational diabetes mellitus in Italy |
title_full |
The short-term economic burden of gestational diabetes mellitus in Italy |
title_fullStr |
The short-term economic burden of gestational diabetes mellitus in Italy |
title_full_unstemmed |
The short-term economic burden of gestational diabetes mellitus in Italy |
title_sort |
short-term economic burden of gestational diabetes mellitus in italy |
publisher |
BMC |
series |
BMC Pregnancy and Childbirth |
issn |
1471-2393 |
publishDate |
2018-02-01 |
description |
Abstract Background The incidence of Gestational Diabetes Mellitus (GDM) is rising in all developed countries. This study aimed at assessing the short-term economic burden of GDM from the Italian healthcare system perspective. Methods A model was built over the last pregnancy trimester (i.e., from the 28th gestational week until childbirth included). The National Hospital Discharge Database (2014) was accessed to estimate delivery outcome probabilities and inpatient costs in GDM and normal pregnancies (i.e., euglycemia). International Classification of Disease-9th Revision-Clinical Modification (ICD9-CM) diagnostic codes and Diagnosis-Related Group (DRG) codes were used to identify GDM cases and different types of delivery (i.e., vaginal or cesarean) within the database. Neonatal outcomes probabilities were estimated from the literature and included macrosomia, hypoglycemia, hyperbilirubinemia, shoulder dystocia, respiratory distress, and brachial plexus injury. Additional data sources such as regional documents, official price and tariff lists, national statistics and expert opinion were used to populate the model. The average cost per case was calculated at national level to estimate the annual economic burden of GDM. One-way sensitivity analyses and Monte Carlo simulations were performed to quantify the uncertainty around base case results. Results The amount of pregnancies complicated by GDM in Italy was assessed at 54,783 in 2014 using a prevalence rate of 10.9%. The antenatal outpatient cost per case was estimated at €43.7 in normal pregnancies compared to €370.6 in GDM patients, which is equivalent to a weighted sum of insulin- (14%; €1034.6) and diet- (86%; €262.5) treated women’s costs. Inpatient delivery costs were assessed at €1601.6 and €1150.3 for euglycemic women and their infants, and at €1835.0 and €1407.7 for GDM women and their infants, respectively. Thus, the overall cost per case difference between GDM and normal pregnancies was equal to €817.8 (+ 29.2%), resulting in an economic burden of about €44.8 million in 2014 at national level. Probabilistic sensitivity analysis yielded a cost per case difference ranging between €464.9 and €1164.8 in 80% of simulations. Conclusions The economic burden of GDM in Italy is substantial even accounting for short-term medical costs only. Future research also addressing long-term consequences from a broader societal perspective is recommended. |
topic |
Gestational diabetes mellitus (GDM) Hospital discharge database (HDD) Delivery outcomes Costs Italy |
url |
http://link.springer.com/article/10.1186/s12884-018-1689-1 |
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