Diagnostic value of MicroPure imaging for malignant thyroid nodule microcalcification and its correlation with the oncogene expression in nodules

• Main Author: Fu-Juan Liu
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-09-01
• Series: Journal of Hainan Medical University
• Subjects: Thyroid cancer; MicroPure imaging; Microcalcification; Proliferation; Invasion; Angiogenesis
• Online Access: http://www.hnykdxxb.com/PDF/201717/24.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To study the diagnostic value of MicroPure imaging for malignant thyroid nodule microcalcification and its correlation with the oncogene expression in nodules. Methods: Patients with thyroid nodules confirmed by ultrasound in Dongtai People's Hospital between June 2014 and October 2016 were selected and divided into those with malignant thyroid nodules and benign thyroid nodules according to the pathological results, and MicroPure imaging technology was used to judge the microcalcification and further divide the malignant thyroid nodules into microcalcification (+) and microcalcification (-). The biopsy tissue was collected to detect the expression of cyclin, cell invasion molecules and angiogenesis molecules. Results: CyclinD1, CyclinE, MCM7, MMP2, MMP13, Vimentin, N-cadherin, Twist, HIF-1α, VEGF-C,VEGFR-2, VEGFR-3, Ang-2 and Tie-2 expression in malignant thyroid nodules of microcalcification (+) group and microcalcification (-) group were significantly higher than those of benign group while CyclinG2 and P53 expression were significantly lower than those of benign group; CyclinD1, CyclinE, MCM7, MMP2, MMP13, Vimentin, N-cadherin, Twist, HIF-1α, VEGF-C, VEGFR-2, VEGFR-3, Ang-2 and Tie-2 expression in malignant thyroid nodules of microcalcification (+) group were significantly higher than those of microcalcification (-) group while CyclinG2 and P53 expression were significantly lower than those of microcalcification (-) group. Conclusion: Malignant thyroid nodule microcalcification detected by MicroPure imaging has a good correlation with cancer cell proliferation, invasion and angiogenesis.