Association of polymorphisms the trigger receptor gene expressed by myeloid cells (<i>TREM-1</i>) in sporadic congenital heart defects without chromosome anomalies

Association of polymorphisms the trigger receptor gene expressed by myeloid cells (<i>TREM-1</i>) in sporadic congenital heart defects without chromosome anomalies

Eight polymorphic loci in the TREM-1 gene (rs1817537, rs3804277, rs6910730, rs7768162, rs2234246, rs4711668, rs9471535 and rs2234237) were genotyped in 131 children with congenital heart defects (CHD) without proven chromosomal anomalies, and 103 conditionally healthy children (control group) matche...

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Main Authors: A. V. Shabaldin, A. V. Tsepokina, S. A. Shmulevich, N. S. Deeva, A. V. Ponasenko, L. V. Antonova, E. V. Shabaldina
Format: Article
Language:Russian
Published: SPb RAACI 2020-05-01
Series:Medicinskaâ Immunologiâ
Subjects:
trem-1
congenital heart defects
genetic polymorphism
inter-locus interactions
Online Access:https://www.mimmun.ru/mimmun/article/view/1948
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spelling doaj-2d01fd644e024a168193648d6c287b7d2021-07-29T09:02:36ZrusSPb RAACIMedicinskaâ Immunologiâ1563-06252313-741X2020-05-0122350551810.15789/1563-0625-AOP-19481282Association of polymorphisms the trigger receptor gene expressed by myeloid cells (<i>TREM-1</i>) in sporadic congenital heart defects without chromosome anomaliesA. V. Shabaldin0A. V. Tsepokina1S. A. Shmulevich2N. S. Deeva3A. V. Ponasenko4L. V. Antonova5E. V. Shabaldina6Research Institute for Complex Issues of Cardiovascular DiseasesResearch Institute for Complex Issues of Cardiovascular DiseasesResearch Institute for Complex Issues of Cardiovascular Diseases; Kemerovo L. Barbarash Cardiological DispensaryResearch Institute for Complex Issues of Cardiovascular DiseasesResearch Institute for Complex Issues of Cardiovascular DiseasesResearch Institute for Complex Issues of Cardiovascular DiseasesKemerovo State Medical UniversityEight polymorphic loci in the TREM-1 gene (rs1817537, rs3804277, rs6910730, rs7768162, rs2234246, rs4711668, rs9471535 and rs2234237) were genotyped in 131 children with congenital heart defects (CHD) without proven chromosomal anomalies, and 103 conditionally healthy children (control group) matched for age and gender. Genotyping was performed by polymerase chain reaction (PCR) using TaqMan probes. The frequency of these genotypes was checked for Hardy–Weinberg equilibrium using a free tool (http://bioinfo.iconcologia.net/SNPstats). Analysis of inter-locus interactions was performed by Multifactor Dimensionality Reduction method. It was shown that the combination of four loci, i.e., rs1817537, rs3804277, rs2234246 and rs7768162 may determine susceptibility and persistence for CHD without chromosomal diseases. Increased CHD risk is associated with two-locus model rs1817537*G/G – rs3804277*T/T (OR = 8.26) and three-locus model rs2234246*C/T – rs1817537*C/G – rs7768162*A/G (OR = 13.76). The two-locus model rs1817537*С/С – rs3804277*T/T (OR = 0.03) and three-locus model rs2234246*T/T – rs1817537*C/C – rs7768162*G/G (OR = 0.03) were associated with a decreased risk for CHD without detectable chromosomal anomalies.https://www.mimmun.ru/mimmun/article/view/1948trem-1congenital heart defectsgenetic polymorphisminter-locus interactions
collection DOAJ
language Russian
format Article
sources DOAJ
author A. V. Shabaldin
A. V. Tsepokina
S. A. Shmulevich
N. S. Deeva
A. V. Ponasenko
L. V. Antonova
E. V. Shabaldina
spellingShingle A. V. Shabaldin
A. V. Tsepokina
S. A. Shmulevich
N. S. Deeva
A. V. Ponasenko
L. V. Antonova
E. V. Shabaldina
Association of polymorphisms the trigger receptor gene expressed by myeloid cells (<i>TREM-1</i>) in sporadic congenital heart defects without chromosome anomalies
Medicinskaâ Immunologiâ
trem-1
congenital heart defects
genetic polymorphism
inter-locus interactions
author_facet A. V. Shabaldin
A. V. Tsepokina
S. A. Shmulevich
N. S. Deeva
A. V. Ponasenko
L. V. Antonova
E. V. Shabaldina
author_sort A. V. Shabaldin
title Association of polymorphisms the trigger receptor gene expressed by myeloid cells (<i>TREM-1</i>) in sporadic congenital heart defects without chromosome anomalies
title_short Association of polymorphisms the trigger receptor gene expressed by myeloid cells (<i>TREM-1</i>) in sporadic congenital heart defects without chromosome anomalies
title_full Association of polymorphisms the trigger receptor gene expressed by myeloid cells (<i>TREM-1</i>) in sporadic congenital heart defects without chromosome anomalies
title_fullStr Association of polymorphisms the trigger receptor gene expressed by myeloid cells (<i>TREM-1</i>) in sporadic congenital heart defects without chromosome anomalies
title_full_unstemmed Association of polymorphisms the trigger receptor gene expressed by myeloid cells (<i>TREM-1</i>) in sporadic congenital heart defects without chromosome anomalies
title_sort association of polymorphisms the trigger receptor gene expressed by myeloid cells (<i>trem-1</i>) in sporadic congenital heart defects without chromosome anomalies
publisher SPb RAACI
series Medicinskaâ Immunologiâ
issn 1563-0625
2313-741X
publishDate 2020-05-01
description Eight polymorphic loci in the TREM-1 gene (rs1817537, rs3804277, rs6910730, rs7768162, rs2234246, rs4711668, rs9471535 and rs2234237) were genotyped in 131 children with congenital heart defects (CHD) without proven chromosomal anomalies, and 103 conditionally healthy children (control group) matched for age and gender. Genotyping was performed by polymerase chain reaction (PCR) using TaqMan probes. The frequency of these genotypes was checked for Hardy–Weinberg equilibrium using a free tool (http://bioinfo.iconcologia.net/SNPstats). Analysis of inter-locus interactions was performed by Multifactor Dimensionality Reduction method. It was shown that the combination of four loci, i.e., rs1817537, rs3804277, rs2234246 and rs7768162 may determine susceptibility and persistence for CHD without chromosomal diseases. Increased CHD risk is associated with two-locus model rs1817537*G/G – rs3804277*T/T (OR = 8.26) and three-locus model rs2234246*C/T – rs1817537*C/G – rs7768162*A/G (OR = 13.76). The two-locus model rs1817537*С/С – rs3804277*T/T (OR = 0.03) and three-locus model rs2234246*T/T – rs1817537*C/C – rs7768162*G/G (OR = 0.03) were associated with a decreased risk for CHD without detectable chromosomal anomalies.
topic trem-1
congenital heart defects
genetic polymorphism
inter-locus interactions
url https://www.mimmun.ru/mimmun/article/view/1948
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