Albisporachelin, a New Hydroxamate Type Siderophore from the Deep Ocean Sediment-Derived Actinomycete Amycolatopsis albispora WP1T

• Main Authors: Qihao Wu, Robert W. Deering, Gaiyun Zhang, Bixia Wang, Xin Li, Jiadong Sun, Jianwei Chen, Huawei Zhang, David C. Rowley, Hong Wang
• Format: Article
• Language: English
• Published: MDPI AG 2018-06-01
• Series: Marine Drugs
• Subjects: Amycolatopsis; siderophore; deep ocean sediment
• Online Access: http://www.mdpi.com/1660-3397/16/6/199

Marine actinobacteria continue to be a rich source for the discovery of structurally diverse secondary metabolites. Here we present a new hydroxymate siderophore produced by Amycolatopsis albispora, a recently described species of this less explored actinomycete genus. Strain WP1T was isolated from sediments collected at −2945 m in the Indian Ocean. The new siderophore, designated albisporachelin, was isolated from iron depleted culture broths and the structure was established by 1D and 2D NMR and MS/MS experiments, and application of a modified Marfey’s method. Albisporachelin is composed of one N-methylated-formylated/hydroxylated l-ornithine (N-Me-fh-l-Orn), one l-serine (l-Ser), one formylated/hydroxylated l-ornithine (fh-l-Orn) and a cyclo-N-methylated-hydroxylated l-ornithine (cyclo-N-Me-h-l-Orn).