Neoadjuvant Immune-Checkpoint Blockade in Triple-Negative Breast Cancer: Current Evidence and Literature-Based Meta-Analysis of Randomized Trials
Chemotherapy based on the sequential use of anthracyclines and taxanes has long represented the most efficacious approach in the management of early-stage, triple-negative breast cancer, whose aggressive behavior is widely renowned. This standard chemotherapy backbone was subsequently enriched by th...
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doaj-2d069f1bd6634cafb59e87d5810e91e02020-11-25T03:16:29ZengMDPI AGCancers2072-66942020-09-01122497249710.3390/cancers12092497Neoadjuvant Immune-Checkpoint Blockade in Triple-Negative Breast Cancer: Current Evidence and Literature-Based Meta-Analysis of Randomized TrialsDaniele Marinelli0Marco Mazzotta1Laura Pizzuti2Eriseld Krasniqi3Teresa Gamucci4Clara Natoli5Antonino Grassadonia6Nicola Tinari7Silverio Tomao8Isabella Sperduti9Giuseppe Sanguineti10Andrea Botticelli11Agnese Fabbri12Claudio Botti13Gennaro Ciliberto14Maddalena Barba15Patrizia Vici16Department of Clinical and Molecular Medicine, Oncology Unit, Sant’Andrea Hospital, Sapienza University, 00189 Rome, ItalyDivision of Medical Oncology 2, IRCCS Regina Elena National Cancer Institute, 00144 Rome, ItalyDivision of Medical Oncology 2, IRCCS Regina Elena National Cancer Institute, 00144 Rome, ItalyDivision of Medical Oncology 2, IRCCS Regina Elena National Cancer Institute, 00144 Rome, ItalyMedical Oncology, Sandro Pertini Hospital, 00157 Rome, ItalyDepartment of Medical, Oral and Biotechnological Sciences and CeSI-MeT, G. D’Annunzio University, 66100 Chieti, ItalyDepartment of Medical, Oral and Biotechnological Sciences and CeSI-MeT, G. D’Annunzio University, 66100 Chieti, ItalyDepartment of Medical, Oral and Biotechnological Sciences and CeSI-MeT, G. D’Annunzio University, 66100 Chieti, ItalyDepartment of Radiological, Oncological and Anatomo-Pathological Sciences, Policlinico Umberto I, ‘Sapienza’ University of Rome, 00161 Rome, ItalyBiostatistics Unit, IRCCS Regina Elena National Cancer Institute, 00144 Rome, ItalyDepartment of Radiation Oncology, IRCCS Regina Elena National Cancer Institute, 00144 Rome, ItalyMedical Oncology Unit B, Policlinico Umberto I, 00161 Rome, ItalyMedical Oncology Unit, Belcolle Hospital, 01100 Viterbo, ItalyDepartment of Surgery, IRCCS Regina Elena National Cancer Institute, 00144 Rome, ItalyScientific Direction, IRCCS Regina Elena National Cancer Institute, 00144 Rome, ItalyDivision of Medical Oncology 2, IRCCS Regina Elena National Cancer Institute, 00144 Rome, ItalyDivision of Medical Oncology 2, IRCCS Regina Elena National Cancer Institute, 00144 Rome, ItalyChemotherapy based on the sequential use of anthracyclines and taxanes has long represented the most efficacious approach in the management of early-stage, triple-negative breast cancer, whose aggressive behavior is widely renowned. This standard chemotherapy backbone was subsequently enriched by the use of carboplatin, based on its association with increased pathologic complete response and efficacy in the metastatic setting. Following the results from the IMpassion130 trial, the recent approval of the immunotherapic agent atezolizumab in combination with chemotherapy as first-line treatment for programmed-death ligand 1-positive, unresectable locally advanced, or metastatic triple-negative breast cancer increasingly fueled the flourishing of trials of immune-checkpoint inhibitors in the early setting. In this work, we review the most recent inherent literature in light of key methodological issues and provide a quantitative summary of the results from phase II–III randomized trials of immunotherapic agents combined with chemotherapy in the setting of interest. Hints regarding future directions are also discussed.https://www.mdpi.com/2072-6694/12/9/2497triple-negative breast cancerimmune check point inhibitorneoadjuvant therapymeta-analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Daniele Marinelli Marco Mazzotta Laura Pizzuti Eriseld Krasniqi Teresa Gamucci Clara Natoli Antonino Grassadonia Nicola Tinari Silverio Tomao Isabella Sperduti Giuseppe Sanguineti Andrea Botticelli Agnese Fabbri Claudio Botti Gennaro Ciliberto Maddalena Barba Patrizia Vici |
spellingShingle |
Daniele Marinelli Marco Mazzotta Laura Pizzuti Eriseld Krasniqi Teresa Gamucci Clara Natoli Antonino Grassadonia Nicola Tinari Silverio Tomao Isabella Sperduti Giuseppe Sanguineti Andrea Botticelli Agnese Fabbri Claudio Botti Gennaro Ciliberto Maddalena Barba Patrizia Vici Neoadjuvant Immune-Checkpoint Blockade in Triple-Negative Breast Cancer: Current Evidence and Literature-Based Meta-Analysis of Randomized Trials Cancers triple-negative breast cancer immune check point inhibitor neoadjuvant therapy meta-analysis |
author_facet |
Daniele Marinelli Marco Mazzotta Laura Pizzuti Eriseld Krasniqi Teresa Gamucci Clara Natoli Antonino Grassadonia Nicola Tinari Silverio Tomao Isabella Sperduti Giuseppe Sanguineti Andrea Botticelli Agnese Fabbri Claudio Botti Gennaro Ciliberto Maddalena Barba Patrizia Vici |
author_sort |
Daniele Marinelli |
title |
Neoadjuvant Immune-Checkpoint Blockade in Triple-Negative Breast Cancer: Current Evidence and Literature-Based Meta-Analysis of Randomized Trials |
title_short |
Neoadjuvant Immune-Checkpoint Blockade in Triple-Negative Breast Cancer: Current Evidence and Literature-Based Meta-Analysis of Randomized Trials |
title_full |
Neoadjuvant Immune-Checkpoint Blockade in Triple-Negative Breast Cancer: Current Evidence and Literature-Based Meta-Analysis of Randomized Trials |
title_fullStr |
Neoadjuvant Immune-Checkpoint Blockade in Triple-Negative Breast Cancer: Current Evidence and Literature-Based Meta-Analysis of Randomized Trials |
title_full_unstemmed |
Neoadjuvant Immune-Checkpoint Blockade in Triple-Negative Breast Cancer: Current Evidence and Literature-Based Meta-Analysis of Randomized Trials |
title_sort |
neoadjuvant immune-checkpoint blockade in triple-negative breast cancer: current evidence and literature-based meta-analysis of randomized trials |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2020-09-01 |
description |
Chemotherapy based on the sequential use of anthracyclines and taxanes has long represented the most efficacious approach in the management of early-stage, triple-negative breast cancer, whose aggressive behavior is widely renowned. This standard chemotherapy backbone was subsequently enriched by the use of carboplatin, based on its association with increased pathologic complete response and efficacy in the metastatic setting. Following the results from the IMpassion130 trial, the recent approval of the immunotherapic agent atezolizumab in combination with chemotherapy as first-line treatment for programmed-death ligand 1-positive, unresectable locally advanced, or metastatic triple-negative breast cancer increasingly fueled the flourishing of trials of immune-checkpoint inhibitors in the early setting. In this work, we review the most recent inherent literature in light of key methodological issues and provide a quantitative summary of the results from phase II–III randomized trials of immunotherapic agents combined with chemotherapy in the setting of interest. Hints regarding future directions are also discussed. |
topic |
triple-negative breast cancer immune check point inhibitor neoadjuvant therapy meta-analysis |
url |
https://www.mdpi.com/2072-6694/12/9/2497 |
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