Funny current and cardiac rhythm: insights from HCN knockout mouse models

Funny current and cardiac rhythm: insights from HCN knockout mouse models

In the adult animal the sinoatrial node (SAN) rhythmically generates a depolarizing wave that propagates to the rest of the heart. However, the SAN is more than a simple clock; it is a clock that adjusts its pace according to the metabolic requirements of the organism. The Hyperpolarization-activate...

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Bibliographic Details
Main Authors: Mirko eBaruscotti, Annalisa eBucchi, Andrea eBarbuti, Dario eDiFrancesco
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-07-01
Series:Frontiers in Physiology
Subjects:
Sinoatrial Node
cardiac pacemaking
HCN KO mouse models
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00240/full

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