Opinion on reconsideration of lung cancer risk from domestic radon exposure
Two extensive collaborative meta studies including 13 residential case-control studies from Europe and 7 from North America have demonstrated that domestic radon clearly poses a risk for lung cancer at exposure levels approaching those for underground miners. An excess risk for lung cancer of 0.08–0...
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doaj-2d0ece984feb4d179a53e5fc42fa284e2021-02-21T04:36:40ZengKeAi Communications Co., Ltd.Radiation Medicine and Protection2666-55572020-03-01114854Opinion on reconsideration of lung cancer risk from domestic radon exposureRobert Nilsson0Jian Tong1Vinča Institute of Nuclear Sciences, Laboratory for Physical Chemistry, University of Belgrade, 11000, Belgrade, Serbia; Corresponding author. Department of Physical Chemistry, Vinča Institute of Nuclear Sciences, University of BelgradeMike Petrovica Alasa bb, POB 522, 11001, Vinča-Belgrade, Serbia.School of Public Health, Medical College of Soochow University, Suzhou, 215123, Suzhou, ChinaTwo extensive collaborative meta studies including 13 residential case-control studies from Europe and 7 from North America have demonstrated that domestic radon clearly poses a risk for lung cancer at exposure levels approaching those for underground miners. An excess risk for lung cancer of 0.08–0.16 per 100 Bq/m3 increase in radon concentration was obtained, with a positive trend of increased relative risk at above 200 Bq/m3.However, estimation of the cancer risk associated with domestic radon obtained by the pooling of multiple case-control studies has led to inaccuracies of the derived risk estimates in the low dose range, mainly due to smoking misclassification bias, uncertainties with respect to radon dosimetry, the histopathological characterization of lung cancers, as well as confounding by co-exposures with tobacco smoke and other indoor air pollutants. Together with a lack of biological plausibility, these deficiencies have a negative impact on the reliability of reported statistical relations between radon exposure and lung cancer at concentrations below 200 Bq/m3.It is vital that costly remedial actions to reduce domestic radon exposure are based on a scientifically robust risk assessment, and in view of aforementioned flaws, the hitherto proposed risk estimates need to be reconsidered.http://www.sciencedirect.com/science/article/pii/S2666555720300010Domestic radonDosimetryLung cancerHistopathologyRisk estimateMisclassification |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Robert Nilsson Jian Tong |
spellingShingle |
Robert Nilsson Jian Tong Opinion on reconsideration of lung cancer risk from domestic radon exposure Radiation Medicine and Protection Domestic radon Dosimetry Lung cancer Histopathology Risk estimate Misclassification |
author_facet |
Robert Nilsson Jian Tong |
author_sort |
Robert Nilsson |
title |
Opinion on reconsideration of lung cancer risk from domestic radon exposure |
title_short |
Opinion on reconsideration of lung cancer risk from domestic radon exposure |
title_full |
Opinion on reconsideration of lung cancer risk from domestic radon exposure |
title_fullStr |
Opinion on reconsideration of lung cancer risk from domestic radon exposure |
title_full_unstemmed |
Opinion on reconsideration of lung cancer risk from domestic radon exposure |
title_sort |
opinion on reconsideration of lung cancer risk from domestic radon exposure |
publisher |
KeAi Communications Co., Ltd. |
series |
Radiation Medicine and Protection |
issn |
2666-5557 |
publishDate |
2020-03-01 |
description |
Two extensive collaborative meta studies including 13 residential case-control studies from Europe and 7 from North America have demonstrated that domestic radon clearly poses a risk for lung cancer at exposure levels approaching those for underground miners. An excess risk for lung cancer of 0.08–0.16 per 100 Bq/m3 increase in radon concentration was obtained, with a positive trend of increased relative risk at above 200 Bq/m3.However, estimation of the cancer risk associated with domestic radon obtained by the pooling of multiple case-control studies has led to inaccuracies of the derived risk estimates in the low dose range, mainly due to smoking misclassification bias, uncertainties with respect to radon dosimetry, the histopathological characterization of lung cancers, as well as confounding by co-exposures with tobacco smoke and other indoor air pollutants. Together with a lack of biological plausibility, these deficiencies have a negative impact on the reliability of reported statistical relations between radon exposure and lung cancer at concentrations below 200 Bq/m3.It is vital that costly remedial actions to reduce domestic radon exposure are based on a scientifically robust risk assessment, and in view of aforementioned flaws, the hitherto proposed risk estimates need to be reconsidered. |
topic |
Domestic radon Dosimetry Lung cancer Histopathology Risk estimate Misclassification |
url |
http://www.sciencedirect.com/science/article/pii/S2666555720300010 |
work_keys_str_mv |
AT robertnilsson opiniononreconsiderationoflungcancerriskfromdomesticradonexposure AT jiantong opiniononreconsiderationoflungcancerriskfromdomesticradonexposure |
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