Electroporation-Based Treatments in Small Animal Veterinary Oral and Maxillofacial Oncology
Electroporation is a method of inducing an increase in permeability of the cell membrane through the application of an electric field and can be used as a delivery method for introducing molecules of interest (e.g., chemotherapeutics or plasmid DNA) into cells. Electroporation-based treatments (i.e....
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2020-09-01
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doaj-2d1457d2c9774129b4a06780f126f0ce2020-11-25T03:54:57ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692020-09-01710.3389/fvets.2020.575911575911Electroporation-Based Treatments in Small Animal Veterinary Oral and Maxillofacial OncologyAna Nemec0Nina Milevoj1Urša Lampreht Tratar2Gregor Serša3Maja Čemažar4Nataša Tozon5Small Animal Clinic, Veterinary Faculty, University of Ljubljana, Ljubljana, SloveniaSmall Animal Clinic, Veterinary Faculty, University of Ljubljana, Ljubljana, SloveniaInstitute of Oncology Ljubljana, Ljubljana, SloveniaInstitute of Oncology Ljubljana, Ljubljana, SloveniaInstitute of Oncology Ljubljana, Ljubljana, SloveniaSmall Animal Clinic, Veterinary Faculty, University of Ljubljana, Ljubljana, SloveniaElectroporation is a method of inducing an increase in permeability of the cell membrane through the application of an electric field and can be used as a delivery method for introducing molecules of interest (e.g., chemotherapeutics or plasmid DNA) into cells. Electroporation-based treatments (i.e., electrochemotherapy, gene electrotransfer, and their combinations) have been shown to be safe and effective in veterinary oncology, but they are currently mostly recommended for the treatment of those solid tumors for which clients have declined surgery and/or radiotherapy. Published data show that electroporation-based treatments are also safe, simple, fast and cost-effective treatment alternatives for selected oral and maxillofacial tumors, especially small squamous cell carcinoma and malignant melanoma tumors not involving the bone in dogs. In these patients, a good local response to treatment is expected to result in increased survival time with good quality of life. Despite emerging evidence of the clinical efficacy of electroporation-based treatments for oral and maxillofacial tumors, further investigation is needed to optimize treatment protocols, improve clinical data reporting and better understand the mechanisms of patients' response to the treatment.https://www.frontiersin.org/article/10.3389/fvets.2020.575911/fullelectroporationelectrochemotherapy (ECT)gene electrotransferoral tumorsdogscats |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ana Nemec Nina Milevoj Urša Lampreht Tratar Gregor Serša Maja Čemažar Nataša Tozon |
spellingShingle |
Ana Nemec Nina Milevoj Urša Lampreht Tratar Gregor Serša Maja Čemažar Nataša Tozon Electroporation-Based Treatments in Small Animal Veterinary Oral and Maxillofacial Oncology Frontiers in Veterinary Science electroporation electrochemotherapy (ECT) gene electrotransfer oral tumors dogs cats |
author_facet |
Ana Nemec Nina Milevoj Urša Lampreht Tratar Gregor Serša Maja Čemažar Nataša Tozon |
author_sort |
Ana Nemec |
title |
Electroporation-Based Treatments in Small Animal Veterinary Oral and Maxillofacial Oncology |
title_short |
Electroporation-Based Treatments in Small Animal Veterinary Oral and Maxillofacial Oncology |
title_full |
Electroporation-Based Treatments in Small Animal Veterinary Oral and Maxillofacial Oncology |
title_fullStr |
Electroporation-Based Treatments in Small Animal Veterinary Oral and Maxillofacial Oncology |
title_full_unstemmed |
Electroporation-Based Treatments in Small Animal Veterinary Oral and Maxillofacial Oncology |
title_sort |
electroporation-based treatments in small animal veterinary oral and maxillofacial oncology |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Veterinary Science |
issn |
2297-1769 |
publishDate |
2020-09-01 |
description |
Electroporation is a method of inducing an increase in permeability of the cell membrane through the application of an electric field and can be used as a delivery method for introducing molecules of interest (e.g., chemotherapeutics or plasmid DNA) into cells. Electroporation-based treatments (i.e., electrochemotherapy, gene electrotransfer, and their combinations) have been shown to be safe and effective in veterinary oncology, but they are currently mostly recommended for the treatment of those solid tumors for which clients have declined surgery and/or radiotherapy. Published data show that electroporation-based treatments are also safe, simple, fast and cost-effective treatment alternatives for selected oral and maxillofacial tumors, especially small squamous cell carcinoma and malignant melanoma tumors not involving the bone in dogs. In these patients, a good local response to treatment is expected to result in increased survival time with good quality of life. Despite emerging evidence of the clinical efficacy of electroporation-based treatments for oral and maxillofacial tumors, further investigation is needed to optimize treatment protocols, improve clinical data reporting and better understand the mechanisms of patients' response to the treatment. |
topic |
electroporation electrochemotherapy (ECT) gene electrotransfer oral tumors dogs cats |
url |
https://www.frontiersin.org/article/10.3389/fvets.2020.575911/full |
work_keys_str_mv |
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