Ligand-Based and Docking-Based Virtual Screening of MDM2 Inhibitors as Potent Anticancer Agents

Ligand-Based and Docking-Based Virtual Screening of MDM2 Inhibitors as Potent Anticancer Agents

A ligand-based and docking-based virtual screening was carried out to identify novel MDM2 inhibitors. A pharmacophore model with four features was used for virtual screening, followed by molecular docking. Seventeen compounds were selected for an in vitro MDM2 inhibition assay, and compounds AO-476/...

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Bibliographic Details
Main Authors:	Bing-Hui Li, Jun-Qi Ge, Ya-Li Wang, Li-Jun Wang, Qi Zhang, Cong Bian
Format:	Article
Language:	English
Published:	Hindawi Limited 2021-01-01
Series:	Computational and Mathematical Methods in Medicine
Online Access:	http://dx.doi.org/10.1155/2021/3195957

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