RAC1B Induces SMAD7 via USP26 to Suppress TGFβ1-Dependent Cell Migration in Mesenchymal-Subtype Carcinoma Cells

RAC1B Induces SMAD7 via USP26 to Suppress TGFβ1-Dependent Cell Migration in Mesenchymal-Subtype Carcinoma Cells

The small GTPase RAC1B has been shown to act as a powerful inhibitor of the transforming growth factor (TGF)β type I receptor ALK5 and TGFβ1/ALK5-induced epithelial–mesenchymal transition and cell motility. However, the precise mechanism has remained elusive. RNAi-mediated knockdown of RAC1B in the...

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Bibliographic Details
Main Authors:	Hendrik Ungefroren, Anuradha Kumarasinghe, Melina Musfeldt, Christian Fiedler, Hendrik Lehnert, Jens-Uwe Marquardt
Format:	Article
Language:	English
Published:	MDPI AG 2020-06-01
Series:	Cancers
Subjects:	cell migration CRISPR/Cas9 pancreatic ductal adenocarcinoma RAC1B SMAD7 TGFβ
Online Access:	https://www.mdpi.com/2072-6694/12/6/1545

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