Clinical characteristics of distal gastric cancer in young adults from Northeastern Brazil
Abstract Background It has been suggested that distal gastric carcinoma (GC) in younger patients has a more aggressive outcome than in older patients, however this is a controversial issue. The aim of this study was to compare clinicopathological features between younger and older patients with GC i...
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doaj-2d1e1cd502714d7bbc942b2528d3fb432020-11-24T21:33:24ZengBMCBMC Cancer1471-24072018-02-011811710.1186/s12885-018-3995-4Clinical characteristics of distal gastric cancer in young adults from Northeastern BrazilManuel B. Braga-Neto0Jessica Gomes Carneiro1Alzira M. de Castro Barbosa2Igor S. Silva3Danielle C. Maia4Felipe S. Maciel5Rafael Jorge Alves de Alcântara6Paulo Roberto L. Vasconscelos7Lucia L. B. C. Braga8Department of Internal Medicine, Federal University of CearáClinical Research Unit, Federal University of CearáHospital Universitário Walter Cantídio, Federal University of CearáClinical Research Unit, Federal University of CearáHospital Universitário Walter Cantídio, Federal University of CearáClinical Research Unit, Federal University of CearáClinical Research Unit, Federal University of CearáDepartment of Surgery, Federal University of CearáDepartment of Internal Medicine, Federal University of CearáAbstract Background It has been suggested that distal gastric carcinoma (GC) in younger patients has a more aggressive outcome than in older patients, however this is a controversial issue. The aim of this study was to compare clinicopathological features between younger and older patients with GC in Northeastern Brazil. Methods A total of 207 patients with distal GC (41 patients ≤45 years, considered younger group, and 166 > 45 years, considered older group) were evaluated prospectively during a 6 year period. Results The mean patient age in the young group was 37.41 years old and 64.43 years in the older group. No significant difference was found regarding gender, area of residence, history of alcohol consumption, chronic tobacco smoking. Prevalence of first-degree GC history was 12.5% (7.3% in younger group vs. 13.9% in older; p < 0.46). The most frequent symptom was gastric pain and weight loss. Diffuse infiltrative cancer was more frequently seen in younger patients (70.70% vs. 33.70%, respectively; p < 0.01), as was histologically less differentiated tumors (63.40% vs. 33.10%; p < 0.01) and stage IV of GC (48.80% vs. 30.70%; p < 0.015). Five-year survival, evaluated in 82 patients, was lower in younger patients (p = 0.045); however, after adjusting for stage of GC in the multivariate analysis, this association did not remain significant. Family history of GC and gender had no impact on survival. Conclusions Younger patients showed higher prevalence of diffuse type of Lauren and lower survival that was attributed to higher rate of advanced stage of GC. Gastric cancer screening strategies should also be considered in younger individuals, especially in areas of high prevalence. Further studies are warranted to determine risk factors associated with gastric cancer in young adults.http://link.springer.com/article/10.1186/s12885-018-3995-4Distal gastric cancerYoung adultsRisk factorsBrazil |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Manuel B. Braga-Neto Jessica Gomes Carneiro Alzira M. de Castro Barbosa Igor S. Silva Danielle C. Maia Felipe S. Maciel Rafael Jorge Alves de Alcântara Paulo Roberto L. Vasconscelos Lucia L. B. C. Braga |
spellingShingle |
Manuel B. Braga-Neto Jessica Gomes Carneiro Alzira M. de Castro Barbosa Igor S. Silva Danielle C. Maia Felipe S. Maciel Rafael Jorge Alves de Alcântara Paulo Roberto L. Vasconscelos Lucia L. B. C. Braga Clinical characteristics of distal gastric cancer in young adults from Northeastern Brazil BMC Cancer Distal gastric cancer Young adults Risk factors Brazil |
author_facet |
Manuel B. Braga-Neto Jessica Gomes Carneiro Alzira M. de Castro Barbosa Igor S. Silva Danielle C. Maia Felipe S. Maciel Rafael Jorge Alves de Alcântara Paulo Roberto L. Vasconscelos Lucia L. B. C. Braga |
author_sort |
Manuel B. Braga-Neto |
title |
Clinical characteristics of distal gastric cancer in young adults from Northeastern Brazil |
title_short |
Clinical characteristics of distal gastric cancer in young adults from Northeastern Brazil |
title_full |
Clinical characteristics of distal gastric cancer in young adults from Northeastern Brazil |
title_fullStr |
Clinical characteristics of distal gastric cancer in young adults from Northeastern Brazil |
title_full_unstemmed |
Clinical characteristics of distal gastric cancer in young adults from Northeastern Brazil |
title_sort |
clinical characteristics of distal gastric cancer in young adults from northeastern brazil |
publisher |
BMC |
series |
BMC Cancer |
issn |
1471-2407 |
publishDate |
2018-02-01 |
description |
Abstract Background It has been suggested that distal gastric carcinoma (GC) in younger patients has a more aggressive outcome than in older patients, however this is a controversial issue. The aim of this study was to compare clinicopathological features between younger and older patients with GC in Northeastern Brazil. Methods A total of 207 patients with distal GC (41 patients ≤45 years, considered younger group, and 166 > 45 years, considered older group) were evaluated prospectively during a 6 year period. Results The mean patient age in the young group was 37.41 years old and 64.43 years in the older group. No significant difference was found regarding gender, area of residence, history of alcohol consumption, chronic tobacco smoking. Prevalence of first-degree GC history was 12.5% (7.3% in younger group vs. 13.9% in older; p < 0.46). The most frequent symptom was gastric pain and weight loss. Diffuse infiltrative cancer was more frequently seen in younger patients (70.70% vs. 33.70%, respectively; p < 0.01), as was histologically less differentiated tumors (63.40% vs. 33.10%; p < 0.01) and stage IV of GC (48.80% vs. 30.70%; p < 0.015). Five-year survival, evaluated in 82 patients, was lower in younger patients (p = 0.045); however, after adjusting for stage of GC in the multivariate analysis, this association did not remain significant. Family history of GC and gender had no impact on survival. Conclusions Younger patients showed higher prevalence of diffuse type of Lauren and lower survival that was attributed to higher rate of advanced stage of GC. Gastric cancer screening strategies should also be considered in younger individuals, especially in areas of high prevalence. Further studies are warranted to determine risk factors associated with gastric cancer in young adults. |
topic |
Distal gastric cancer Young adults Risk factors Brazil |
url |
http://link.springer.com/article/10.1186/s12885-018-3995-4 |
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