Ficus deltoidea: A Potential Alternative Medicine for Diabetes Mellitus
Ficus deltoidea from the Moraceae family has been scientifically proven to reduce hyperglycemia at different prandial states. In this study, we evaluate the mechanisms that underlie antihyperglycemic action of Ficus deltoidea. The results had shown that hot aqueous extract of Ficus deltoidea stimula...
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doaj-2d279f20fc0c4f5d8bae0171e987be162020-11-24T22:49:32ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882012-01-01201210.1155/2012/632763632763Ficus deltoidea: A Potential Alternative Medicine for Diabetes MellitusZainah Adam0Shafii Khamis1Amin Ismail2Muhajir Hamid3Medical Technology Division, Malaysian Nuclear Agency, Bangi, Selangor 43000 Kajang, MalaysiaMedical Technology Division, Malaysian Nuclear Agency, Bangi, Selangor 43000 Kajang, MalaysiaDepartment of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor 43400 Serdang, MalaysiaDepartment of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Selangor 43400 Serdang, MalaysiaFicus deltoidea from the Moraceae family has been scientifically proven to reduce hyperglycemia at different prandial states. In this study, we evaluate the mechanisms that underlie antihyperglycemic action of Ficus deltoidea. The results had shown that hot aqueous extract of Ficus deltoidea stimulated insulin secretion significantly with the highest magnitude of stimulation was 7.31-fold (P<0.001). The insulin secretory actions of the hot aqueous extract involved K+ ATP channel-dependent and K+ ATP-channel-independent pathway. The extract also has the ability to induce the usage of intracellular Ca2+ to trigger insulin release. The ethanolic and methanolic extracts enhanced basal and insulin-mediated glucose uptake into adipocytes cells. The extracts possess either insulin-mimetic or insulin-sensitizing property or combination of both properties during enhancing glucose uptake into such cells. Meanwhile, the hot aqueous and methanolic extracts augmented basal and insulin-stimulated adiponectin secretion from adipocytes cells. From this study, it is suggested that Ficus deltoidea has the potential to be developed as future oral antidiabetic agent.http://dx.doi.org/10.1155/2012/632763 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zainah Adam Shafii Khamis Amin Ismail Muhajir Hamid |
spellingShingle |
Zainah Adam Shafii Khamis Amin Ismail Muhajir Hamid Ficus deltoidea: A Potential Alternative Medicine for Diabetes Mellitus Evidence-Based Complementary and Alternative Medicine |
author_facet |
Zainah Adam Shafii Khamis Amin Ismail Muhajir Hamid |
author_sort |
Zainah Adam |
title |
Ficus deltoidea: A Potential Alternative Medicine for Diabetes Mellitus |
title_short |
Ficus deltoidea: A Potential Alternative Medicine for Diabetes Mellitus |
title_full |
Ficus deltoidea: A Potential Alternative Medicine for Diabetes Mellitus |
title_fullStr |
Ficus deltoidea: A Potential Alternative Medicine for Diabetes Mellitus |
title_full_unstemmed |
Ficus deltoidea: A Potential Alternative Medicine for Diabetes Mellitus |
title_sort |
ficus deltoidea: a potential alternative medicine for diabetes mellitus |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2012-01-01 |
description |
Ficus deltoidea from the Moraceae family has been scientifically proven to reduce hyperglycemia at different prandial states. In this study, we evaluate the mechanisms that underlie antihyperglycemic action of Ficus deltoidea. The results had shown that hot aqueous extract of Ficus deltoidea stimulated insulin secretion significantly with the highest magnitude of stimulation was 7.31-fold (P<0.001). The insulin secretory actions of the hot aqueous extract involved K+ ATP channel-dependent and K+ ATP-channel-independent pathway. The extract also has the ability to induce the usage of intracellular Ca2+ to trigger insulin release. The ethanolic and methanolic extracts enhanced basal and insulin-mediated glucose uptake into adipocytes cells. The extracts possess either insulin-mimetic or insulin-sensitizing property or combination of both properties during enhancing glucose uptake into such cells. Meanwhile, the hot aqueous and methanolic extracts augmented basal and insulin-stimulated adiponectin secretion from adipocytes cells. From this study, it is suggested that Ficus deltoidea has the potential to be developed as future oral antidiabetic agent. |
url |
http://dx.doi.org/10.1155/2012/632763 |
work_keys_str_mv |
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