Differential tDCS and tACS Effects on Working Memory-Related Neural Activity and Resting-State Connectivity
Transcranial direct and alternating current stimulation (tDCS and tACS, respectively) entail capability to modulate human brain dynamics and cognition. However, the comparability of these approaches at the level of large-scale functional networks has not been thoroughly investigated. In this study,...
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Frontiers Media S.A.
2020-01-01
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Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2019.01440/full |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kilian Abellaneda-Pérez Kilian Abellaneda-Pérez Lídia Vaqué-Alcázar Lídia Vaqué-Alcázar Ruben Perellón-Alfonso Ruben Perellón-Alfonso Núria Bargalló Núria Bargalló Min-Fang Kuo Alvaro Pascual-Leone Alvaro Pascual-Leone Alvaro Pascual-Leone Michael A. Nitsche Michael A. Nitsche David Bartrés-Faz David Bartrés-Faz David Bartrés-Faz |
spellingShingle |
Kilian Abellaneda-Pérez Kilian Abellaneda-Pérez Lídia Vaqué-Alcázar Lídia Vaqué-Alcázar Ruben Perellón-Alfonso Ruben Perellón-Alfonso Núria Bargalló Núria Bargalló Min-Fang Kuo Alvaro Pascual-Leone Alvaro Pascual-Leone Alvaro Pascual-Leone Michael A. Nitsche Michael A. Nitsche David Bartrés-Faz David Bartrés-Faz David Bartrés-Faz Differential tDCS and tACS Effects on Working Memory-Related Neural Activity and Resting-State Connectivity Frontiers in Neuroscience transcranial direct current stimulation (tDCS) transcranial alternating current stimulation (tACS) resting-state functional magnetic resonance imaging (rs-fMRI) task-based functional magnetic resonance imaging (tb-fMRI) working memory (WM) |
author_facet |
Kilian Abellaneda-Pérez Kilian Abellaneda-Pérez Lídia Vaqué-Alcázar Lídia Vaqué-Alcázar Ruben Perellón-Alfonso Ruben Perellón-Alfonso Núria Bargalló Núria Bargalló Min-Fang Kuo Alvaro Pascual-Leone Alvaro Pascual-Leone Alvaro Pascual-Leone Michael A. Nitsche Michael A. Nitsche David Bartrés-Faz David Bartrés-Faz David Bartrés-Faz |
author_sort |
Kilian Abellaneda-Pérez |
title |
Differential tDCS and tACS Effects on Working Memory-Related Neural Activity and Resting-State Connectivity |
title_short |
Differential tDCS and tACS Effects on Working Memory-Related Neural Activity and Resting-State Connectivity |
title_full |
Differential tDCS and tACS Effects on Working Memory-Related Neural Activity and Resting-State Connectivity |
title_fullStr |
Differential tDCS and tACS Effects on Working Memory-Related Neural Activity and Resting-State Connectivity |
title_full_unstemmed |
Differential tDCS and tACS Effects on Working Memory-Related Neural Activity and Resting-State Connectivity |
title_sort |
differential tdcs and tacs effects on working memory-related neural activity and resting-state connectivity |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroscience |
issn |
1662-453X |
publishDate |
2020-01-01 |
description |
Transcranial direct and alternating current stimulation (tDCS and tACS, respectively) entail capability to modulate human brain dynamics and cognition. However, the comparability of these approaches at the level of large-scale functional networks has not been thoroughly investigated. In this study, 44 subjects were randomly assigned to receive sham (N = 15), tDCS (N = 15), or tACS (N = 14). The first electrode (anode in tDCS) was positioned over the left dorsolateral prefrontal cortex, the target area, and the second electrode (cathode in tDCS) was placed over the right supraorbital region. tDCS was delivered with a constant current of 2 mA. tACS was fixed to 2 mA peak-to-peak with 6 Hz frequency. Stimulation was applied concurrently with functional magnetic resonance imaging (fMRI) acquisitions, both at rest and during the performance of a verbal working memory (WM) task. After stimulation, subjects repeated the fMRI WM task. Our results indicated that at rest, tDCS increased functional connectivity particularly within the default-mode network (DMN), while tACS decreased it. When comparing both fMRI WM tasks, it was observed that tDCS displayed decreased brain activity post-stimulation as compared to online. Conversely, tACS effects were driven by neural increases online as compared to post-stimulation. Interestingly, both effects primarily occurred within DMN-related areas. Regarding the differences in each fMRI WM task, during the online fMRI WM task, tACS engaged distributed neural resources which did not overlap with the WM-dependent activity pattern, but with some posterior DMN regions. In contrast, during the post-stimulation fMRI WM task, tDCS strengthened prefrontal DMN deactivations, being these activity reductions associated with faster responses. Furthermore, it was observed that tDCS neural responses presented certain consistency across distinct fMRI modalities, while tACS did not. In sum, tDCS and tACS modulate fMRI-derived network dynamics differently. However, both effects seem to focus on DMN regions and the WM network-DMN shift, which are highly affected in aging and disease. Thus, albeit exploratory and needing further replication with larger samples, our results might provide a refined understanding of how the DMN functioning can be externally modulated through commonly used non-invasive brain stimulation techniques, which may be of eventual clinical relevance. |
topic |
transcranial direct current stimulation (tDCS) transcranial alternating current stimulation (tACS) resting-state functional magnetic resonance imaging (rs-fMRI) task-based functional magnetic resonance imaging (tb-fMRI) working memory (WM) |
url |
https://www.frontiersin.org/article/10.3389/fnins.2019.01440/full |
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doaj-2d28f3445def433db22473159c6561d22020-11-25T02:18:06ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2020-01-011310.3389/fnins.2019.01440497934Differential tDCS and tACS Effects on Working Memory-Related Neural Activity and Resting-State ConnectivityKilian Abellaneda-Pérez0Kilian Abellaneda-Pérez1Lídia Vaqué-Alcázar2Lídia Vaqué-Alcázar3Ruben Perellón-Alfonso4Ruben Perellón-Alfonso5Núria Bargalló6Núria Bargalló7Min-Fang Kuo8Alvaro Pascual-Leone9Alvaro Pascual-Leone10Alvaro Pascual-Leone11Michael A. Nitsche12Michael A. Nitsche13David Bartrés-Faz14David Bartrés-Faz15David Bartrés-Faz16Department of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Barcelona, SpainInstitute of Biomedical Research August Pi i Sunyer, Barcelona, SpainDepartment of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Barcelona, SpainInstitute of Biomedical Research August Pi i Sunyer, Barcelona, SpainDepartment of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Barcelona, SpainInstitute of Biomedical Research August Pi i Sunyer, Barcelona, SpainHospital Clínic de Barcelona, Magnetic Resonance Image Core Facility, Institute of Biomedical Research August Pi i Sunyer, Barcelona, SpainHospital Clínic de Barcelona, Neuroradiology Section, Radiology Service, Centre de Diagnòstic per la Imatge, Barcelona, SpainLeibniz Research Centre for Working Environment and Human Factors, Dortmund, GermanyHinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, United StatesDepartment of Neurology, Harvard Medical School, Boston, MA, United StatesGuttmann Brain Health Institute, Institut Universitari de Neurorehabilitació Guttmann, Autonomous University of Barcelona, Bellaterra, SpainLeibniz Research Centre for Working Environment and Human Factors, Dortmund, GermanyDepartment of Neurology, University Medical Hospital Bergmannsheil, Bochum, GermanyDepartment of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Barcelona, SpainInstitute of Biomedical Research August Pi i Sunyer, Barcelona, SpainGuttmann Brain Health Institute, Institut Universitari de Neurorehabilitació Guttmann, Autonomous University of Barcelona, Bellaterra, SpainTranscranial direct and alternating current stimulation (tDCS and tACS, respectively) entail capability to modulate human brain dynamics and cognition. However, the comparability of these approaches at the level of large-scale functional networks has not been thoroughly investigated. In this study, 44 subjects were randomly assigned to receive sham (N = 15), tDCS (N = 15), or tACS (N = 14). The first electrode (anode in tDCS) was positioned over the left dorsolateral prefrontal cortex, the target area, and the second electrode (cathode in tDCS) was placed over the right supraorbital region. tDCS was delivered with a constant current of 2 mA. tACS was fixed to 2 mA peak-to-peak with 6 Hz frequency. Stimulation was applied concurrently with functional magnetic resonance imaging (fMRI) acquisitions, both at rest and during the performance of a verbal working memory (WM) task. After stimulation, subjects repeated the fMRI WM task. Our results indicated that at rest, tDCS increased functional connectivity particularly within the default-mode network (DMN), while tACS decreased it. When comparing both fMRI WM tasks, it was observed that tDCS displayed decreased brain activity post-stimulation as compared to online. Conversely, tACS effects were driven by neural increases online as compared to post-stimulation. Interestingly, both effects primarily occurred within DMN-related areas. Regarding the differences in each fMRI WM task, during the online fMRI WM task, tACS engaged distributed neural resources which did not overlap with the WM-dependent activity pattern, but with some posterior DMN regions. In contrast, during the post-stimulation fMRI WM task, tDCS strengthened prefrontal DMN deactivations, being these activity reductions associated with faster responses. Furthermore, it was observed that tDCS neural responses presented certain consistency across distinct fMRI modalities, while tACS did not. In sum, tDCS and tACS modulate fMRI-derived network dynamics differently. However, both effects seem to focus on DMN regions and the WM network-DMN shift, which are highly affected in aging and disease. Thus, albeit exploratory and needing further replication with larger samples, our results might provide a refined understanding of how the DMN functioning can be externally modulated through commonly used non-invasive brain stimulation techniques, which may be of eventual clinical relevance.https://www.frontiersin.org/article/10.3389/fnins.2019.01440/fulltranscranial direct current stimulation (tDCS)transcranial alternating current stimulation (tACS)resting-state functional magnetic resonance imaging (rs-fMRI)task-based functional magnetic resonance imaging (tb-fMRI)working memory (WM) |