Pimpinella anisum in the treatment of functional dyspepsia: A double-blind, randomized clinical trial
Background: We aimed to evaluate the effects of Pimpinella anisum (anise) from Apiaceae family on relieving the symptoms of postprandial distress syndrome (PDS) in this double-blind randomized clinical trial. Materials and Methods: Totally, 107 patients attending the gastroenterology clinic, aged 18...
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doaj-2d2d172e3b9347d684319672846feebf2020-11-24T23:10:41ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362015-01-012011321Pimpinella anisum in the treatment of functional dyspepsia: A double-blind, randomized clinical trialS Ashraffodin GhoshegirMohammad MazaheriAlireza GhannadiAwat FeiziMahmoud BabaeianMaryam TanhaeeMehrdad KarimiPeyman AdibiBackground: We aimed to evaluate the effects of Pimpinella anisum (anise) from Apiaceae family on relieving the symptoms of postprandial distress syndrome (PDS) in this double-blind randomized clinical trial. Materials and Methods: Totally, 107 patients attending the gastroenterology clinic, aged 18-65 years, diagnosed with PDS according to ROME III criteria and signed a written consent form were enrolled. They were randomized to receive either anise or placebo, blindly, for 4 weeks. Anise group included 47 patients and received anise powders, 3 g after each meal (3 times/day). Control group involved 60 patients and received placebo powders (corn starch), 3 gafter each meal (3 times/day). The severity of Functional dyspepsia (FD) symptoms was assessed by FD severity scale. Assessments were done at baseline and by the end of weeks 2, 4 and 12. Mean scores of severity of FD symptoms and the frequency distribution of patients across the study period were compared. Results: The age, sex, body mass index, smoking history, and coffee drinking pattern of the intervention and control groups were not significantly different. Mean (standard deviation) total scores of FD severity scale before intervention in the anise and control groups were 10.6 (4.1) and 10.96 (4.1), respectively (P = 0.6). They were 7.04 (4.1) and 12.30 (4.3) by week 2, respectively (P = 0.0001), 2.44 (4.2) and 13.05 (5.2) by week 4, respectively (P = 0.0001), and 1.08 (3.8) and 13.30 (6.2) by week 12, respectively (P = 0.0001). Conclusion: This study showed the effectiveness of anise in relieving the symptoms of postpartum depression. The findings were consistent across the study period at weeks 2, 4 and 12.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2015;volume=20;issue=1;spage=13;epage=21;aulast=GhoshegirAnisefunctional dyspepsiaPimpinella anisumpostprandial distress syndrome |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
S Ashraffodin Ghoshegir Mohammad Mazaheri Alireza Ghannadi Awat Feizi Mahmoud Babaeian Maryam Tanhaee Mehrdad Karimi Peyman Adibi |
spellingShingle |
S Ashraffodin Ghoshegir Mohammad Mazaheri Alireza Ghannadi Awat Feizi Mahmoud Babaeian Maryam Tanhaee Mehrdad Karimi Peyman Adibi Pimpinella anisum in the treatment of functional dyspepsia: A double-blind, randomized clinical trial Journal of Research in Medical Sciences Anise functional dyspepsia Pimpinella anisum postprandial distress syndrome |
author_facet |
S Ashraffodin Ghoshegir Mohammad Mazaheri Alireza Ghannadi Awat Feizi Mahmoud Babaeian Maryam Tanhaee Mehrdad Karimi Peyman Adibi |
author_sort |
S Ashraffodin Ghoshegir |
title |
Pimpinella anisum in the treatment of functional dyspepsia: A double-blind, randomized clinical trial |
title_short |
Pimpinella anisum in the treatment of functional dyspepsia: A double-blind, randomized clinical trial |
title_full |
Pimpinella anisum in the treatment of functional dyspepsia: A double-blind, randomized clinical trial |
title_fullStr |
Pimpinella anisum in the treatment of functional dyspepsia: A double-blind, randomized clinical trial |
title_full_unstemmed |
Pimpinella anisum in the treatment of functional dyspepsia: A double-blind, randomized clinical trial |
title_sort |
pimpinella anisum in the treatment of functional dyspepsia: a double-blind, randomized clinical trial |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Research in Medical Sciences |
issn |
1735-1995 1735-7136 |
publishDate |
2015-01-01 |
description |
Background: We aimed to evaluate the effects of Pimpinella anisum (anise) from Apiaceae family on relieving the symptoms of postprandial distress syndrome (PDS) in this double-blind randomized clinical trial. Materials and Methods: Totally, 107 patients attending the gastroenterology clinic, aged 18-65 years, diagnosed with PDS according to ROME III criteria and signed a written consent form were enrolled. They were randomized to receive either anise or placebo, blindly, for 4 weeks. Anise group included 47 patients and received anise powders, 3 g after each meal (3 times/day). Control group involved 60 patients and received placebo powders (corn starch), 3 gafter each meal (3 times/day). The severity of Functional dyspepsia (FD) symptoms was assessed by FD severity scale. Assessments were done at baseline and by the end of weeks 2, 4 and 12. Mean scores of severity of FD symptoms and the frequency distribution of patients across the study period were compared. Results: The age, sex, body mass index, smoking history, and coffee drinking pattern of the intervention and control groups were not significantly different. Mean (standard deviation) total scores of FD severity scale before intervention in the anise and control groups were 10.6 (4.1) and 10.96 (4.1), respectively (P = 0.6). They were 7.04 (4.1) and 12.30 (4.3) by week 2, respectively (P = 0.0001), 2.44 (4.2) and 13.05 (5.2) by week 4, respectively (P = 0.0001), and 1.08 (3.8) and 13.30 (6.2) by week 12, respectively (P = 0.0001). Conclusion: This study showed the effectiveness of anise in relieving the symptoms of postpartum depression. The findings were consistent across the study period at weeks 2, 4 and 12. |
topic |
Anise functional dyspepsia Pimpinella anisum postprandial distress syndrome |
url |
http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2015;volume=20;issue=1;spage=13;epage=21;aulast=Ghoshegir |
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