Jacobian Maps Reveal Under-reported Brain Regions Sensitive to Extreme Binge Ethanol Intoxication in the Rat
Individuals aged 12–20 years drink 11% of all alcohol consumed in the United States with more than 90% consumed in the form of binge drinking. Early onset alcohol use is a strong predictor of future alcohol dependence. The study of the effects of excessive alcohol use on the human brain is hampered...
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doaj-2d3543350da04c35adc5786d6e1834322020-11-25T00:45:58ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292018-12-011210.3389/fnana.2018.00108429715Jacobian Maps Reveal Under-reported Brain Regions Sensitive to Extreme Binge Ethanol Intoxication in the RatQingyu Zhao0Michael Fritz1Adolf Pfefferbaum2Edith V. Sullivan3Kilian M. Pohl4Natalie M. Zahr5Natalie M. Zahr6Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, United StatesDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, United StatesNeuroscience Program, SRI International, Menlo Park, CA, United StatesDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, United StatesNeuroscience Program, SRI International, Menlo Park, CA, United StatesDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, United StatesNeuroscience Program, SRI International, Menlo Park, CA, United StatesIndividuals aged 12–20 years drink 11% of all alcohol consumed in the United States with more than 90% consumed in the form of binge drinking. Early onset alcohol use is a strong predictor of future alcohol dependence. The study of the effects of excessive alcohol use on the human brain is hampered by limited information regarding the quantity and frequency of exposure to alcohol. Animal models can control for age at alcohol exposure onset and enable isolation of neural substrates of exposure to different patterns and quantities of ethanol (EtOH). As with humans, a frequently used binge exposure model is thought to produce dependence and affect predominantly corticolimbic brain regions. in vivo neuroimaging enables animals models to be examined longitudinally, allowing for each animal to serve as its own control. Accordingly, we conducted 3 magnetic resonance imaging (MRI) sessions (baseline, binge, recovery) to track structure throughout the brains of wild type Wistar rats to test the hypothesis that binge EtOH exposure affects specific brain regions in addition to corticolimbic circuitry. Voxel-based comparisons of 13 EtOH- vs. 12 water- exposed animals identified significant thalamic shrinkage and lateral ventricular enlargement as occurring with EtOH exposure, but recovering with a week of abstinence. By contrast, pretectal nuclei and superior and inferior colliculi shrank in response to binge EtOH treatment but did not recover with abstinence. These results identify brainstem structures that have been relatively underreported but are relevant for localizing neurocircuitry relevant to the dynamic course of alcoholism.https://www.frontiersin.org/article/10.3389/fnana.2018.00108/fullalcoholaddictionrodentcolliculusthalamus |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qingyu Zhao Michael Fritz Adolf Pfefferbaum Edith V. Sullivan Kilian M. Pohl Natalie M. Zahr Natalie M. Zahr |
spellingShingle |
Qingyu Zhao Michael Fritz Adolf Pfefferbaum Edith V. Sullivan Kilian M. Pohl Natalie M. Zahr Natalie M. Zahr Jacobian Maps Reveal Under-reported Brain Regions Sensitive to Extreme Binge Ethanol Intoxication in the Rat Frontiers in Neuroanatomy alcohol addiction rodent colliculus thalamus |
author_facet |
Qingyu Zhao Michael Fritz Adolf Pfefferbaum Edith V. Sullivan Kilian M. Pohl Natalie M. Zahr Natalie M. Zahr |
author_sort |
Qingyu Zhao |
title |
Jacobian Maps Reveal Under-reported Brain Regions Sensitive to Extreme Binge Ethanol Intoxication in the Rat |
title_short |
Jacobian Maps Reveal Under-reported Brain Regions Sensitive to Extreme Binge Ethanol Intoxication in the Rat |
title_full |
Jacobian Maps Reveal Under-reported Brain Regions Sensitive to Extreme Binge Ethanol Intoxication in the Rat |
title_fullStr |
Jacobian Maps Reveal Under-reported Brain Regions Sensitive to Extreme Binge Ethanol Intoxication in the Rat |
title_full_unstemmed |
Jacobian Maps Reveal Under-reported Brain Regions Sensitive to Extreme Binge Ethanol Intoxication in the Rat |
title_sort |
jacobian maps reveal under-reported brain regions sensitive to extreme binge ethanol intoxication in the rat |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroanatomy |
issn |
1662-5129 |
publishDate |
2018-12-01 |
description |
Individuals aged 12–20 years drink 11% of all alcohol consumed in the United States with more than 90% consumed in the form of binge drinking. Early onset alcohol use is a strong predictor of future alcohol dependence. The study of the effects of excessive alcohol use on the human brain is hampered by limited information regarding the quantity and frequency of exposure to alcohol. Animal models can control for age at alcohol exposure onset and enable isolation of neural substrates of exposure to different patterns and quantities of ethanol (EtOH). As with humans, a frequently used binge exposure model is thought to produce dependence and affect predominantly corticolimbic brain regions. in vivo neuroimaging enables animals models to be examined longitudinally, allowing for each animal to serve as its own control. Accordingly, we conducted 3 magnetic resonance imaging (MRI) sessions (baseline, binge, recovery) to track structure throughout the brains of wild type Wistar rats to test the hypothesis that binge EtOH exposure affects specific brain regions in addition to corticolimbic circuitry. Voxel-based comparisons of 13 EtOH- vs. 12 water- exposed animals identified significant thalamic shrinkage and lateral ventricular enlargement as occurring with EtOH exposure, but recovering with a week of abstinence. By contrast, pretectal nuclei and superior and inferior colliculi shrank in response to binge EtOH treatment but did not recover with abstinence. These results identify brainstem structures that have been relatively underreported but are relevant for localizing neurocircuitry relevant to the dynamic course of alcoholism. |
topic |
alcohol addiction rodent colliculus thalamus |
url |
https://www.frontiersin.org/article/10.3389/fnana.2018.00108/full |
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