Contribution of efflux to the emergence of isoniazid and multidrug resistance in Mycobacterium tuberculosis.

Contribution of efflux to the emergence of isoniazid and multidrug resistance in Mycobacterium tuberculosis.

Multidrug resistant (MDR) tuberculosis is caused by Mycobacterium tuberculosis resistant to isoniazid and rifampicin, the two most effective drugs used in tuberculosis therapy. Here, we investigated the mechanism by which resistance towards isoniazid develops and how overexpression of efflux pumps f...

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Bibliographic Details
Main Authors: Diana Machado, Isabel Couto, João Perdigão, Liliana Rodrigues, Isabel Portugal, Pedro Baptista, Bruno Veigas, Leonard Amaral, Miguel Viveiros
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22493700/pdf/?tool=EBI

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