An Unusual Presentation of Granulomatosis with Polyangiitis

• Main Authors: Rakhee Sodhi, Sushant Khanduri, Varuna Jethani, Shirazi Nadia, Manoj Kumar
• Format: Article
• Language: English
• Published: Mashhad University of Medical Sciences 2017-09-01
• Series: Journal of Cardio-Thoracic Medicine
• Subjects: antinuclear antibody; anti-neutrophil cytoplasmic antibody; Granulomatosis With Polyangiitis; sepsis
• Online Access: http://jctm.mums.ac.ir/article_9236_b5d86aad598b97d478f58cad806e8335.pdf

The granulomatosis with polyangiitis (GPA), formerly known as Wegener’s granulomatosis, is a pauci-immune vasculitis involving small- and medium-sized blood vessels. Classically, the patients inflicted with this disease present with a triad of necrotizing granulomatous inflammation of the respiratory tract, cutaneous necrotizing vasculitis, and glomerulonephritis (GN). The antinuclear (ANA) and anti-neutrophil cytoplasmic antibodies (ANCA) are considered as relatively specific markers of the disease. Herein, we presented the case of a patient who initially presented with sepsis but did not respond to the conventional antibiotics and later diagnosed with GPA.The granulomatosis with polyangiitis (GPA), formerly known as Wegener’s granulomatosis, is a pauci-immune vasculitis involving small- and medium-sized blood vessels. Classically, the patients inflicted with this disease present with a triad of necrotizing granulomatous inflammation of the respiratory tract, cutaneous necrotizing vasculitis, and glomerulonephritis (GN).The antinuclear (ANA) and anti-neutrophil cytoplasmic antibodies (ANCA) are considered as relatively specific markers of the disease. Herein, we presented the case of a patient who initially presented with sepsis but did not respond to the conventional antibiotics and later diagnosed with GPA.