In vitro Type II Restriction of Bacteriophage DNA With Modified Pyrimidines

In vitro Type II Restriction of Bacteriophage DNA With Modified Pyrimidines

To counteract host-encoded restriction systems, bacteriophages (phages) incorporate modified bases in their genomes. For example, phages carry in their genomes modified pyrimidines such as 5-hydroxymethyl-cytosine (5hmC) in T4gt deficient in α- and β-glycosyltransferases, glucosylated-5-hydroxymethy...

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Bibliographic Details
Main Authors: Kiersten Flodman, Ivan R. Corrêa, Nan Dai, Peter Weigele, Shuang-yong Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Microbiology
Subjects:
Type II restriction
modified phage genome
phage SP8
phage Xp12 genome sequence
5hmdU DNA kinase
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2020.604618/full

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