The mechanisms of hydroxychloroquine in rheumatoid arthritis treatment: Inhibition of dendritic cell functions via Toll like receptor 9 signaling

The mechanisms of hydroxychloroquine in rheumatoid arthritis treatment: Inhibition of dendritic cell functions via Toll like receptor 9 signaling

Hydroxychloroquine (HCQ) is one of the most commonly prescribed immune-suppressants in treating rheumatoid arthritis (RA). Our previous research showed that HCQ suppressed RA development by inhibiting T follicular helper (Tfh) cells directly. Dendritic cells (DCs) serve as the link between innate an...

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Bibliographic Details
Main Authors: Jiaochan Han, Xing Li, Xiaoqing Luo, Juan He, Xuechan Huang, Qingyou Zhou, Yanping Han, Hongyu Jie, Jian Zhuang, Yehao Li, Fangyuan Yang, Zeqing Zhai, Shufan Wu, Yi He, Bin Yang, Erwei Sun
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Hydroxychloroquine
Rheumatoid arthritis
Dendritic cells
Toll like receptor 9
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220310404

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